SR 7826

Name: SR 7826
Brand: Tocris Bioscience
SKU: 5626

Tocris Bioscience, part of Bio-Techne | Catalog # 5626

Citations (7)

COA / SDS

Potent and selective LIMK inhibitor; antitumor

Key Product Details

Description:	Potent and selective LIMK inhibitor; antitumor
Chemical Name:	N-(2-Hydroxyethyl)-N'-[4,5-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)phenyl]-N-phenylurea
Purity:	≥98% (HPLC)
Molecular Weight:	387.43

View Full Technical Details for SR 7826

Technical Data
Citations

Biological Activity for SR 7826

SR 7826 is a potent and selective LIMK inhibitor (IC₅₀ values are 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively). Inhibits cofilin phosphorylation in A7r5 cells and suppresses migration and invasion of PC-3 cells in vitro. Orally bioavailable.

Compound Libraries for SR 7826

SR 7826 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for SR 7826

M. Wt	387.43
Formula	C₂₂H₂₁N₅O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1219728-20-7
PubChem ID	45381385
InChi Key	WQAGVQVBDHOHRD-UHFFFAOYSA-N
Smiles	O=C(N(CCO)C4=CC=CC=C4)NC(C=C3)=CC=C3C1=C2C(NC=C2C)=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 7826

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	38.74	100

Preparing Stock Solutions for SR 7826

The following data is based on the product molecular weight 387.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.58 mL	12.91 mL	25.81 mL
5 mM	0.52 mL	2.58 mL	5.16 mL
10 mM	0.26 mL	1.29 mL	2.58 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for SR 7826

References are publications that support the biological activity of the product.

Yin Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors. J.Med.Chem. 2015 PMID: 25621531