SR 7826
Tocris Bioscience, part of Bio-Techne | Catalog # 5626
Potent and selective LIMK inhibitor; antitumor
Key Product Details
Description
Potent and selective LIMK inhibitor; antitumor
Product Description
SR 7826 is a potent and selective LIMK inhibitor (IC50 values are 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively). Inhibits cofilin phosphorylation in A7r5 cells and suppresses migration and invasion of PC-3 cells in vitro. Orally bioavailable.Product Specifications
Molecular Weight
387.43
Formula
C22H21N5O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(2-Hydroxyethyl)-N'-[4,5-methyl-7H-pyrrolo[2,3-d]pyrimidine-4-yl)phenyl]-N-phenylurea
CAS Number
1219728-20-7
PubChem ID
45381385
InChI Key
WQAGVQVBDHOHRD-UHFFFAOYSA-N
SMILES
O=C(N(CCO)C4=CC=CC=C4)NC(C=C3)=CC=C3C1=C2C(NC=C2C)=NC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.74 | 100 |
Preparing Stock Solutions
for SR 7826
The following data is based on the product molecular weight 387.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.58 mL | 12.91 mL | 25.81 mL |
| 5 mM | 0.52 mL | 2.58 mL | 5.16 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.58 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yin Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors. J.Med.Chem. 2015 PMID: 25621531
Product Specific Notices for SR 7826
For research use only
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