11 results for "Prostanoid Receptor Antagonists Small Molecules and Peptides" in Products
Prostanoid Receptor Antagonists: Small Molecules and Peptides
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2α, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled receptors that have distinct tissue distributions and actions.
- DP receptors (DP1-2) are coupled to Gαs. They are expressed in the small intestine, lung, stomach and uterus. ...
Selective EP4 receptor antagonist
| Chemical Name: | N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-4-yl]methyl][1,1'-biphenyl]-2-yl]sulfonyl]-3-methyl-2-thiophenecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective EP2 receptor antagonist
| Chemical Name: | 1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid |
| Purity: | ≥98% (HPLC) |
Selective EP1 receptor antagonist
| Chemical Name: | 8-Chloro-dibenzo(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide |
| Purity: | ≥98% (HPLC) |
Dual TP/DP2 (CRTH2) receptor antagonist
| Alternate Names: | Ramatroban |
| Chemical Name: | (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid |
| Purity: | ≥98% (HPLC) |
EP1 receptor antagonist
| Chemical Name: | 4-[[[2,3-Dihydro-6-[(2-methylpropyl)[(4-methyl-2-thiazolyl)sulfonyl]amino]-1H-indene-5yl]oxy]methyl]benzoic acid |
| Purity: | ≥98% (HPLC) |
Potent and selective prostaglandin D2 receptor antagonist
| Chemical Name: | (3R)-4-[(4-Chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)cyclopent[b]indole-3-acetic acid |
| Purity: | ≥98% (HPLC) |
Potent and highly selective EP3 antagonist
| Chemical Name: | N-[(5-Bromo-2-methoxyphenyl)sulfonyl]-3-[2-(2-naphthalenylmethyl)phenyl]-2-propenamide |
| Purity: | ≥98% (HPLC) |
Potent and selective EP3 antagonist; antiplatelet and antithrombotic
| Chemical Name: | (2E)-3-[1-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-1H-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide |
| Purity: | ≥98% (HPLC) |
High affinity and selective EP4 antagonist
| Alternate Names: | PGN 1531 |
| Chemical Name: | 4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent thromboxane A2 (TP) antagonist
| Alternate Names: | terutroban |
| Chemical Name: | (6R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid |
| Purity: | ≥98% (HPLC) |
High affinity and selective EP4 antagonist
| Chemical Name: | 4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]benzenebutanoic acid |
| Purity: | ≥98% (HPLC) |
