PF 04418948

Tocris Bioscience, part of Bio-Techne | Catalog # 4818

Potent and selective EP2 receptor antagonist
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Key Product Details

Description

Potent and selective EP2 receptor antagonist

View all Prostanoid Receptor Antagonists »

Product Description

PF 04418948 is a potent prostaglandin E receptor 2 antagonist (PTGER2; EP2; IC50 = 16 nM for human EP2 receptors), which displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors and exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. PF 04418948 inhibits PGE2-induced increases in intracellular cAMP in vitro and reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

External Portal Information

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 04418948 is reviewed.

Product Specifications

Molecular Weight

409.41

Formula

C23H20FNO5

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

1-(4-Fluorobenzoyl)-3-[[(6-methoxy-2-naphthalenyl)oxy]methyl]-3-azetidinecarboxylic acid

CAS Number

1078166-57-0

PubChem ID

25114442

InChI Key

LWJGMYMNSNVCEM-UHFFFAOYSA-N

SMILES

FC(C=C4)=CC=C4C(N(C3)CC3(C(O)=O)COC2=CC1=CC=C(OC)C=C1C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.94 100

Preparing Stock Solutions for PF 04418948

The following data is based on the product molecular weight 409.41

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.21 mL 24.43 mL
5 mM 0.49 mL 2.44 mL 4.89 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for PF 04418948

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 04418948

For research use only

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