S 18886
Tocris Bioscience, part of Bio-Techne | Catalog # 5568
Potent thromboxane A2 (TP) antagonist
Key Product Details
Description
Potent thromboxane A2 (TP) antagonist
Alternative Names
terutroban
Product Description
S 18886 is a potent thromboxane A2 (TP) inhibitor (IC50 = 16.4 nM). Inhibits U 46619 (Cat. No. 1932) induced human platelet aggregation and contraction of isolated rabbit saphenous vein in vitro. Also inhibits U 46619 induced increase in tracheal pressure in guinea pigs. Orally available.Product Specifications
Molecular Weight
407.91
Formula
C20H22ClNO4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(6R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid
CAS Number
165538-40-9
PubChem ID
9938840
InChI Key
HWEOXFSBSQIWSY-MRXNPFEDSA-N
SMILES
CC1=CC=C(C[C@H](NS(C2=CC=C(Cl)C=C2)(=O)=O)CC3)C3=C1CCC(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.79 | 100 | |
| Ethanol | 8.16 | 20 with gentle warming |
Preparing Stock Solutions
for S 18886
The following data is based on the product molecular weight 407.91
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.26 mL | 24.52 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.90 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. ACS Med.Chem.Lett. 2014 PMID: 25221659
- Cimetière Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists. Bioorg.Med.Chem.Lett. 1998 PMID: 9871769
Product Specific Notices for S 18886
For research use only
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