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5 results for "PIK3CA Small Molecules and Peptides" in Products

PIK3CA: Small Molecules and Peptides

PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; p85 and p10. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K (1-2). Four isoforms of p110 has been found;

Prototypical PI 3-kinase inhibitor; also inhibits other kinases

Chemical Name: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride
Purity: ≥99% (HPLC)
Prototypical PI 3-kinase inhibitor; also inhibits other kinases

PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro

Chemical Name: 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one
Purity: ≥98% (HPLC)
PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro

Potent and selective mTOR inhibitor

Chemical Name: 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
Purity: ≥98% (HPLC)
Potent and selective mTOR inhibitor

Potent and selective PI 3-kinase p110α inhibitor

Chemical Name: (2S)-N1-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide
Purity: ≥98% (HPLC)
Potent and selective PI 3-kinase p110α inhibitor

Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK

Alternate Names: GSK2126458
Chemical Name: 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
Purity: ≥98% (HPLC)
Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK
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