Torin 2
Tocris Bioscience, part of Bio-Techne | Catalog # 4248
Potent and selective mTOR inhibitor
Product Description
Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively). Activates autophagy. Orally available.Licensing Information
Sold under license from Whitehead Institute for Biomedical Research.Product Specifications
Molecular Weight
432.40
Formula
C24H15F3N4O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
CAS Number
1223001-51-1
PubChem ID
51358113
InChI Key
GUXXEUUYCAYESJ-UHFFFAOYSA-N
SMILES
O=C(C=C3)N(C5=CC=CC(C(F)(F)F)=C5)C2=C3C=NC1=CC=C(C4=CC=C(N)N=C4)C=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.65 | 20 |
Preparing Stock Solutions
for Torin 2
The following data is based on the product molecular weight 432.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.56 mL | 57.82 mL | 115.63 mL |
| 1 mM | 2.31 mL | 11.56 mL | 23.13 mL |
| 2 mM | 1.16 mL | 5.78 mL | 11.56 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.31 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Simioni Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation. Oncotarget 2014 PMID: 25296981
- Galluzzi Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 2017 PMID: 28529316
- Liu Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. J.Med.Chem. 2011 PMID: 21322566
Product Specific Notices for Torin 2
For research use only
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