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10 results for "Multidrug Transporter Inhibitors" in Products

Multidrug Transporter Inhibitors Products

ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families that have a wide diversity of functions and substrates. Specificity has been shown for small and large molecules, highly charged molecules and highly hydrophobic molecule systems such as that for polysaccharides. Multidrug transporters (MDRs) are a specific type of ABC transporter and are commonly overexpressed in cancer cells.

P-glycoprotein (P-gp, ABCB1, MDR1) is a well-characterized human ...

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Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor

Chemical Name: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
Purity: ≥98% (HPLC)
Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also  DHFR and STAT3 inhibitor

Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor

Alternate Names: L-660711
Chemical Name: 3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid
Purity: ≥98% (HPLC)
Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor

MRP and OAT3 inhibitor

Chemical Name: 4-(Dipropylsulfamoyl)benzoic acid
Purity: ≥98% (HPLC)
MRP and OAT3 inhibitor

Potent and selective BCRP inhibitor

Chemical Name: (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester
Purity: ≥98% (HPLC)
Potent and selective BCRP inhibitor

Inhibitor of P-gp-mediated MDR

Alternate Names: Valspodar
Chemical Name: 6-[(2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoic acid]-7-L-valine-cyclosporin A
Purity: ≥98% (HPLC)
Inhibitor of P-gp-mediated MDR

P-gp and BCRP inhibitor

Alternate Names: GF 120918
Chemical Name: N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride
Purity: ≥98% (HPLC)
P-gp and BCRP inhibitor

Selective MRP4 inhibitor

Chemical Name: 5-[(2-Benzothiazolylthio)methyl]-2,4-dihydro-4-methyl-3H-1,2,4-triazole-3-thione
Purity: ≥98% (HPLC)
Selective MRP4 inhibitor

P-gp inhibitor

Chemical Name: 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-2[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine hydrochloride
Purity: ≥98% (HPLC)
P-gp inhibitor

Potent P-glycoprotein (P-gp) inhibitor

Chemical Name: N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarbxamide dihydrochloride
Purity: ≥98% (HPLC)
Potent P-glycoprotein (P-gp) inhibitor

Selective BCRP inhibitor

Chemical Name: N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]benzamide
Purity: ≥98% (HPLC)
Selective BCRP inhibitor
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