MK 571
Tocris Bioscience, part of Bio-Techne | Catalog # 2338
Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor
Key Product Details
Description
Potent CysLT1 (LTD4) inverse agonist. Also MRP1 inhibitor
Alternative Names
L-660711
Product Description
MK 571 is a potent CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM). Antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Also inhibitor of multidrug resistance protein-1 (MRP1) mediated transport; in vitro augments the effects of cytotoxic agents on malignant cells.Product Specifications
Molecular Weight
515.09
Formula
C26H27ClN2O3S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-[[[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]propanoic acid
CAS Number
115104-28-4
PubChem ID
5281888
InChI Key
AXUZQJFHDNNPFG-UXBLZVDNSA-N
SMILES
ClC1=CC=C(C=CC(/C=C/C3=CC(C(SCCC(O)=O)SCCC(N(C)C)=O)=CC=C3)=N2)C2=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.51 | 100 |
Preparing Stock Solutions
for MK 571
The following data is based on the product molecular weight 515.09
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.94 mL | 9.71 mL | 19.41 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.88 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.94 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Dupre Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1. J.Pharmacol.Exp.Ther. 2004 PMID: 14718577
- Blain and Sirois Involvement of LTD4 in allergic pulmonary inflammation in mice: modulation by cysLT1 antagonist MK-571. Prost.Leuko.Essent.Fatty Acids
- Vellenga Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. Br.J.Pharmacol. 1999 PMID: 10385244
Product Specific Notices for MK 571
For research use only
Loading...
Loading...