Probenecid

Product Description

Probenecid is an inhibitor of multidrug resistance-associated proteins (MRP). Probenicid inhibits OAT3, organic acid transport in the kidney and other organs and exhibits inhibitory activity against pannexin 1 channels (IC₅₀ ~ 150 μM). Probenecid potently inhibits SARS-CoV-2 replication in NHBE and Vero E6 cells (IC₅₀ = 1.3 nM and 750 nM, respectively) and reduces lung virus titers in vivo. Probenicid also inhibits influenza A virus replication in vitro and in vivo.

Solubility

Preparing Stock Solutions for Probenecid

The following data is based on the product molecular weight 285.36

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.50 mL	17.52 mL	35.04 mL
5 mM	0.70 mL	3.50 mL	7.01 mL
10 mM	0.35 mL	1.75 mL	3.50 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Murray Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro. Sci.Rep. 2021 PMID: 34508172
• Perwitasai Targeting organic anion transporter 3 with probenecid as a novel anti-influenza a virus strategy. Antimicrob.Agents Chemother. 2013 PMID: 23129053
• Ishikawa Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells. Biol.Pharm.Bull. 2010 PMID: 20190417
• Silverman Probenecid, a gout remedy, inhibits pannexin 1 channels. Am.J.Physiol.Cell Physiol. 2008 PMID: 18596212
• Hammond Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J.Biol.Chem. 2007 PMID: 17374608
• Cunningham Clinical pharmacokinetics of probe. Clin.Pharmacokinet. 1981 PMID: 7011657