Pyrimethamine
Tocris Bioscience, part of Bio-Techne | Catalog # 3918
Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor
Key Product Details
Description
Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor
Product Description
Pyrimethamine is a potent inhibitor of multidrug and toxin extrusion (MATE) transporters (Ki values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR) and STAT3. Decreases proliferation of human autosomal dominant polycystic kidney disease cells.Product Specifications
Molecular Weight
248.71
Formula
C12H13ClN4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
CAS Number
58-14-0
PubChem ID
4993
InChI Key
WKSAUQYGYAYLPV-UHFFFAOYSA-N
SMILES
ClC1=CC=C(C2=C(N)N=C(N)N=C2CC)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.87 | 100 | |
| Ethanol | 2.49 | 10 |
Preparing Stock Solutions
for Pyrimethamine
The following data is based on the product molecular weight 248.71
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.02 mL | 20.10 mL | 40.21 mL |
| 5 mM | 0.80 mL | 4.02 mL | 8.04 mL |
| 10 mM | 0.40 mL | 2.01 mL | 4.02 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zimmerman Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimeth. and pyrimeth. Am.J.Clin.Nutr. 1987 PMID: 3630970
- Takakura Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum.Mol.Genet. 2011 PMID: 21821671
- Ito Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimeth. J.Pharmacol.Exp.Ther. 2010 PMID: 20065018
Product Specific Notices for Pyrimethamine
For research use only
⚠ WARNING: This product can expose you to chemicals including Pyrimethamine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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