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214 results for "Jak2" in Products

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Jak2 Products

Jak1, Jak 2, and Jak3 belong to the Janus Kinases family of protein tyrosine kinases that couple to cytokine receptors once activated by their corresponding ligands. Activation of Jak family members occurs via phosphorylation at two adjacent tyrosine residues as well as potentially one or more serine residues. Jaks activate members of the STAT family of transcription factors by phosphorylating critical tyrosine regulatory sites.

Jak1 is required for the activation of STAT1 and STAT2 in ...

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U0126
Catalog #: 1144
(5)
Citations (675)
Product Documents
Images (1)

Potent, selective inhibitor of MEK1 and 2

Chemical Name:
1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
Potent, selective inhibitor of MEK1 and 2
Catalog #
Availability
Size / Price
Qty
1144/5
1144/25
Bulk Order

Jak2 Antibody (53B7) - BSA Free
Catalog #: NBP2-59451
(3)
Citations (5)
Product Documents
Images (5)
Reactivity:
Human
Details:
Mouse IgG2b Kappa Monoclonal Clone #53B7
Applications:
WB, ELISA, Flow, ICC/IF, Simple Western, + 1 More
Western Blot: Jak2 Antibody (53B7)BSA Free [NBP2-59451]
(5)
Catalog #
Availability
Size / Price
Qty
NBP2-59451-50ul
NBP2-59451-100ul
Bulk Order

Jak2 [p Tyr1007, p Tyr1008] Antibody (SY24-03)
Catalog #: NBP2-67429
(1)
Citations (2)
Product Documents
Images (8)

Recombinant Monoclonal Antibody

Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Monoclonal Clone #SY24-03
Applications:
IHC, WB, ICC/IF, IP
(8)
Catalog #
Availability
Size / Price
Qty
NBP2-67429
Bulk Order

Jak2 Antibody (6-D3)
Catalog #: NBP2-66913
(1)
Citations (1)
Product Documents
Images (6)
Reactivity:
Human, Mouse, Rat
Details:
Mouse IgG2B Monoclonal Clone #6-D3
Applications:
IHC, WB, Flow, ICC/IF, Endotoxin
Western Blot: Jak2 Antibody (6-D3) [NBP2-66913]
(6)
Catalog #
Availability
Size / Price
Qty
NBP2-66913
Bulk Order

CP 690550 citrate
Catalog #: 4556
(1)
Citations (17)
Product Documents
Images (1)

Potent JAK inhibitor

Alternate Names:
Tofacitinib citrate
Chemical Name:
(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile citrate
Purity:
≥98%
Potent JAK inhibitor
Catalog #
Availability
Size / Price
Qty
4556/50
4556/10
Bulk Order

Jak2 Antibody [Alexa Fluor™ Plus 405]
Catalog #: AF2988AFP405
Product Documents
Reactivity:
Mouse, Rat
Details:
Goat IgG Polyclonal
Applications:
WB
Catalog #
Availability
Size / Price
Qty
AF2988AFP405-100UG
Bulk Order

SD 1008
Catalog #: 3035
Citations (9)
Product Documents
Images (1)

JAK2/STAT3 signaling pathway inhibitor

Chemical Name:
(1R,5R,6R,7S)-rel-4-Oxo-8-(phenylmethyl)-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid 6,7-dimethyl ester
Purity:
≥98%
JAK2/STAT3 signaling pathway inhibitor
Catalog #
Availability
Size / Price
Qty
3035/10
3035/50
Bulk Order

Jak2 Antibody
Catalog #: AF2988
Citations (2)
Product Documents
Images (1)
Reactivity:
Mouse, Rat
Details:
Goat IgG Polyclonal
Applications:
WB
Detection of Mouse/Rat Jak2 antibody by Western Blot.
Catalog #
Availability
Size / Price
Qty
AF2988
AF2988-SP
Bulk Order

AG 490
Catalog #: 0414
Citations (73)
Product Documents
Images (1)

EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor

Alternate Names:
Tyrphostin AG 490
Chemical Name:
(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide
Purity:
≥98%
EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
Catalog #
Availability
Size / Price
Qty
0414/10
0414/50
Bulk Order

Jak2 [p Tyr1007] Antibody (SR1129) - BSA Free
Catalog #: NBP3-21579
Product Documents
Images (3)

Recombinant Monoclonal Antibody

Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Monoclonal Clone #SR1129
Applications:
IHC, WB, Flow, ICC/IF, IP
(3)
Catalog #
Availability
Size / Price
Qty
NBP3-21579-100ul
NBP3-21579-50ul
Bulk Order

Lestaurtinib
Catalog #: 3395
Citations (17)
Product Documents
Images (1)

JAK2, FLT3 and TrkA inhibitor; also inhibits AurA and AurB

Alternate Names:
CEP-701
Chemical Name:
(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
Purity:
≥98%
JAK2, FLT3 and TrkA inhibitor; also inhibits AurA and AurB
Catalog #
Availability
Size / Price
Qty
3395/1
Bulk Order

Ruxolitinib
Catalog #: 7064
Citations (24)
Product Documents
Images (1)

Potent and selective JAK1/JAK2 inhibitor; orally bioavailable

Alternate Names:
INCB018424
Chemical Name:
(3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
Purity:
≥98%
Potent and selective JAK1/JAK2 inhibitor; orally bioavailable
Catalog #
Availability
Size / Price
Qty
7064/50
Bulk Order

Jak2 Antibody - BSA Free
Catalog #: NBP1-22975
Product Documents
Images (2)
Reactivity:
Human
Details:
Rabbit IgG Polyclonal
Applications:
IHC, WB, IP
Western Blot: Jak2 Antibody [NBP1-22975]
(2)
Catalog #
Availability
Size / Price
Qty
NBP1-22975
Bulk Order

Jak2 [p Tyr1007, p Tyr1008] Antibody (1A4) - BSA Free
Catalog #: NBP3-26415
Product Documents
Images (4)

Recombinant Monoclonal Antibody

Reactivity:
Human
Details:
Rabbit IgG Monoclonal Clone #1A4
Applications:
IHC, WB, ELISA, IP
Jak2 [p Tyr1007, p Tyr1008] Antibody (1A4)
(4)
Catalog #
Availability
Size / Price
Qty
NBP3-26415-100ul
NBP3-26415-50ul
Bulk Order

Baricitinib
Catalog #: 7222
Citations (8)
Product Documents
Images (1)

Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2

Alternate Names:
INCB 28050
Chemical Name:
1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile
Purity:
≥98%
Highly potent JAK1 and JAK2 inhibitor; also inhibits JAK3 and Tyk2
Catalog #
Availability
Size / Price
Qty
7222/50
Bulk Order

Jak2 Antibody - BSA Free
Catalog #: NBP2-41310
Product Documents
Images (2)
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
IHC, WB, ELISA
Western Blot: Jak2 AntibodyBSA Free [NBP2-41310]
(2)
Catalog #
Availability
Size / Price
Qty
NBP2-41310
NBP2-41310-0.025mg
Bulk Order

Jak2 Antibody (OTI7D12) - Azide and BSA Free
Catalog #: NBP2-71056
Product Documents
Images (2)
Reactivity:
Human, Mouse, Rat
Details:
Mouse IgG2B Monoclonal Clone #OTI7D12
Applications:
IHC
Immunohistochemistry: Jak2 Antibody (OTI7D12) - Azide and BSA Free [NBP2-71056]
(2)
Catalog #
Availability
Size / Price
Qty
NBP2-71056
Bulk Order

Jak2 Antibody - BSA Free
Catalog #: NBP2-55362
Product Documents
Images (2)
Reactivity:
Human
Details:
Rabbit IgG Polyclonal
Applications:
WB, ICC/IF
Western Blot: Jak2 Antibody [NBP2-55362]
(2)
Catalog #
Availability
Size / Price
Qty
NBP2-55362
Bulk Order

Pyridone 6
Catalog #: 6577
Citations (12)
Product Documents
Images (1)

Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable

Alternate Names:
JAK inhibitor I
Chemical Name:
2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one
Purity:
≥98%
Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable
Catalog #
Availability
Size / Price
Qty
6577/10
6577/50
Bulk Order

Ruxolitinib phosphate
Catalog #: 7048
Citations (1)
Product Documents
Images (1)

Phosphate salt of Ruxolitinib (Cat. No. 7064); potent and selective JAK1/JAK2 inhibitor

Chemical Name:
(3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphate
Purity:
≥98%
Phosphate salt of Ruxolitinib (Cat. No. 7064); potent and selective JAK1/JAK2 inhibitor
Catalog #
Availability
Size / Price
Qty
7048/50
Bulk Order

SJ 1008030
Catalog #: 7675
Product Documents
Images (1)

Selective JAK2 Degrader (PROTAC®)

Chemical Name:
4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethyl)benzamide trifluoroacetate
Purity:
≥98%
Selective JAK2 Degrader (PROTAC®)
Catalog #
Availability
Size / Price
Qty
7675/2
Bulk Order

SJ 10542
Catalog #: 7727
Product Documents
Images (1)

Potent and selective JAK2/3 Degrader (PROTAC®)

Chemical Name:
4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propyl)benzamide
Purity:
≥97%
Potent and selective JAK2/3 Degrader (PROTAC®)
Catalog #
Availability
Size / Price
Qty
7727/2
Bulk Order

Jak2 Antibody (OTI7D12)
Catalog #: NBP2-45468
Product Documents
Images (2)
Reactivity:
Human, Mouse, Rat
Details:
Mouse IgG2B Monoclonal Clone #OTI7D12
Applications:
IHC
Immunohistochemistry-Paraffin: Jak2 Antibody (OTI7D12) [NBP2-45468]
(2)
Catalog #
Availability
Size / Price
Qty
NBP2-45468
Bulk Order

Jak2 [p Tyr1007, p Tyr1008] Antibody
Catalog #: NBP3-13138
Product Documents
Images (2)
Reactivity:
Human, Mouse
Details:
Rabbit IgG Polyclonal
Applications:
WB
Western Blot: Jak2 [p Tyr1007, p Tyr1008] Antibody [NBP3-13138]
(2)
Catalog #
Availability
Size / Price
Qty
NBP3-13138
Bulk Order

Jak2 Antibody (4B0K1)
Catalog #: NBP3-15825
Citations (1)
Product Documents
Images (1)

Recombinant Monoclonal Antibody

Reactivity:
Human, Mouse
Details:
Rabbit IgG Monoclonal Clone #4B0K1
Applications:
WB
Immunoprecipitation: Jak2 Antibody (4B0K1) [NBP3-15825]
Catalog #
Availability
Size / Price
Qty
NBP3-15825-20ul
NBP3-15825-100ul
Bulk Order
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