SJ 10542
Tocris Bioscience, part of Bio-Techne | Catalog # 7727
Potent and selective JAK2/3 Degrader (PROTAC®)
Key Product Details
Description
Potent and selective JAK2/3 Degrader (PROTAC®)
Product Description
SJ 10542 is a potent and selective JAK2/3 Degrader (PROTAC®) (DC50 values are 11 nM and 14 nM; Dmax = 92% and 90% for JAK3 and JAK2, respectively); uses a phenyl glutarimide ligand as the cereblon recruiter. Degrades JAK2 in ex vivo cell lines and patient derived xenografts (DC50= <120 nM) and displays high selectivity over GSPT1 and other members of the JAK family.JAK3 antibody validated for Western Blot also available: Catalog # MAB4699.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from St. Jude Children's Research HospitalProduct Specifications
Molecular Weight
818.96
Formula
C41H46N12O5S
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propyl)benzamide
CAS Number
2789678-92-6
PubChem ID
162679331
InChI Key
WBEBZVDAHMXWJN-UHFFFAOYSA-N
SMILES
O=C(NC1=O)CCC1C2=CC=C(N3CCN(CCCNC(C4=CC=C(NC5=NC6=C(C=CN6)C(C7=CN(C8(CC#N)CN(S(CC)(=O)=O)C8)N=C7)=N5)C=C4)=O)CC3)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.95 | 50 |
Preparing Stock Solutions
for SJ 10542
The following data is based on the product molecular weight 818.96
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.44 mL | 12.21 mL | 24.42 mL |
| 2.5 mM | 0.49 mL | 2.44 mL | 4.88 mL |
| 5 mM | 0.24 mL | 1.22 mL | 2.44 mL |
| 25 mM | 0.05 mL | 0.24 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Alcock Development of potent and selective Janus Kinase 2/3 directing PG-PROTACs. ACS Med.Chem.Lett. 2022 PMID: 35300081
Product Specific Notices for SJ 10542
For research use only
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