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Histamine H1 Receptor Antagonists: Small Molecules and Peptides

Histamine H1R (HRH1) is a G-protein coupled 7-transmembrane putative glycoprotein that is implicated in the pathogenesis of asthma and is a major pharmaceutical target for antihistamines. It has been detected as a mixture of monomers and homodimers, with highest concentration in the placenta, followed by brain, lung (produced by airway smooth muscle, bronchial epithelium and macrophages) and other tissues.

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8 results for "Histamine H1 Receptor Antagonists Small Molecules and Peptides" in Products

8 results for "Histamine H1 Receptor Antagonists Small Molecules and Peptides" in Products

Histamine H1 Receptor Antagonists: Small Molecules and Peptides

Histamine H1R (HRH1) is a G-protein coupled 7-transmembrane putative glycoprotein that is implicated in the pathogenesis of asthma and is a major pharmaceutical target for antihistamines. It has been detected as a mixture of monomers and homodimers, with highest concentration in the placenta, followed by brain, lung (produced by airway smooth muscle, bronchial epithelium and macrophages) and other tissues.

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H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker

Chemical Name: α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol
Purity: ≥98% (HPLC)
H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker

Human pregnane X receptor agonist; H1 antagonist

Alternate Names: Meclozine
Chemical Name: 1-[(4-Chlorophenyl)phenylmethyl]4-[(3-methylphenyl)methyl]piperazine dihydrochloride
Purity: ≥99% (HPLC)
Human pregnane X receptor agonist; H1 antagonist

Orally active, potent H1 antagonist; also KV11.1 (hERG) channel blocker

Alternate Names: Hismanal
Chemical Name: 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine
Purity: ≥98% (HPLC)
Orally active, potent H1 antagonist; also KV11.1 (hERG) channel blocker

H1 antagonist

Chemical Name: (2R)-2-[2-[(1R)-1-(4-Chlorophenylethoxy]ethyl]-1-methyl-2-pyrrolidine fumarate
Purity: ≥98% (HPLC)
H1 antagonist

Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant

Alternate Names: Org 3770,6-Azamianserin
Chemical Name: 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Purity: ≥98% (HPLC)
Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant

H1 antagonist; ocular antiallergic agent

Chemical Name: (Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid hydrochloride
Purity: ≥98% (HPLC)
H1 antagonist; ocular antiallergic agent

H1 antagonist

Alternate Names: DPH
Chemical Name: 2-Diphenylmethoxy-N,N-dimethylethanamine hydrochloride
Purity: ≥98% (HPLC)
H1 antagonist

Selective M2 antagonist

Chemical Name: N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate
Purity: ≥98% (HPLC)
Selective M2 antagonist
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