Histamine H1 Receptor Antagonists: Small Molecules and Peptides
Histamine H1R (HRH1) is a G-protein coupled 7-transmembrane putative glycoprotein that is implicated in the pathogenesis of asthma and is a major pharmaceutical target for antihistamines. It has been detected as a mixture of monomers and homodimers, with highest concentration in the placenta, followed by brain, lung (produced by airway smooth muscle, bronchial epithelium and macrophages) and other tissues.
8 results for "Histamine H1 Receptor Antagonists Small Molecules and Peptides" in Products
8 results for "Histamine H1 Receptor Antagonists Small Molecules and Peptides" in Products
Histamine H1 Receptor Antagonists: Small Molecules and Peptides
Histamine H1R (HRH1) is a G-protein coupled 7-transmembrane putative glycoprotein that is implicated in the pathogenesis of asthma and is a major pharmaceutical target for antihistamines. It has been detected as a mixture of monomers and homodimers, with highest concentration in the placenta, followed by brain, lung (produced by airway smooth muscle, bronchial epithelium and macrophages) and other tissues.
H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker
| Chemical Name: | α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol |
| Purity: | ≥98% (HPLC) |
Human pregnane X receptor agonist; H1 antagonist
| Alternate Names: | Meclozine |
| Chemical Name: | 1-[(4-Chlorophenyl)phenylmethyl]4-[(3-methylphenyl)methyl]piperazine dihydrochloride |
| Purity: | ≥99% (HPLC) |
Orally active, potent H1 antagonist; also KV11.1 (hERG) channel blocker
| Alternate Names: | Hismanal |
| Chemical Name: | 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine |
| Purity: | ≥98% (HPLC) |
H1 antagonist
| Chemical Name: | (2R)-2-[2-[(1R)-1-(4-Chlorophenylethoxy]ethyl]-1-methyl-2-pyrrolidine fumarate |
| Purity: | ≥98% (HPLC) |
Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant
| Alternate Names: | Org 3770,6-Azamianserin |
| Chemical Name: | 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine |
| Purity: | ≥98% (HPLC) |
H1 antagonist; ocular antiallergic agent
| Chemical Name: | (Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid hydrochloride |
| Purity: | ≥98% (HPLC) |
H1 antagonist
| Alternate Names: | DPH |
| Chemical Name: | 2-Diphenylmethoxy-N,N-dimethylethanamine hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective M2 antagonist
| Chemical Name: | N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate |
| Purity: | ≥98% (HPLC) |
