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ErbB2/Her2 Products

ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.

670 results for "ErbB2/Her2" in Products

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ErbB2/Her2 Products

ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.

670 results for "ErbB2/Her2" in Products

Flow, CyTOF-ready, InhibCellGro

Recombinant Monoclonal Antibody For Research Use Only

Flow, ICC/IF, IHC

Recombinant Monoclonal Antibody

Simple Plex Human ErbB2/Her2 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

Recombinant Monoclonal Antibody

WB, Flow, IHC, CyTOF-ready, ICC
Flow, ICC

Recombinant Monoclonal Antibody For Research Use Only

WB, Flow, IHC, CyTOF-ready, InhibCellGro
BA

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: 898120
Ctrl

Control for use with Human ErbB2/Her2 Simple Plex Cartridge Kit

BA
Flow, CyTOF-ready, InhibCellGro

Recombinant Monoclonal Antibody For Research Use Only

WB, Simple Western, IHC
Flow, ICC/IF, IHC, WB
Flow

Recombinant Monoclonal Antibody For Research Use Only

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