ER alpha/NR3A1: Small Molecules and Peptides
Estrogen receptor alpha (ER alpha, NR3A1) is a member of the steroid receptor family. The natural ligand for ER is the classic estrogenic compound 17 beta-estradiol. ER alpha is expressed in a wide variety of tissues such as bones, uterus, bladder, ovary, prostate, testis, epididymis, kidney, breast, heart, vessel wall, pituitary and hypothalamus. The estrogen receptor has a variety of central physiological roles, including those involved in maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems. ER alpha has been shown to form homodimers as well as heterodimers with ER beta. Both ER alpha and ER beta can give rise to numerous isoforms.
12 results for "ER alpha/NR3A1 Small Molecules and Peptides" in Products
12 results for "ER alpha/NR3A1 Small Molecules and Peptides" in Products
ER alpha/NR3A1: Small Molecules and Peptides
Estrogen receptor alpha (ER alpha, NR3A1) is a member of the steroid receptor family. The natural ligand for ER is the classic estrogenic compound 17 beta-estradiol. ER alpha is expressed in a wide variety of tissues such as bones, uterus, bladder, ovary, prostate, testis, epididymis, kidney, breast, heart, vessel wall, pituitary and hypothalamus. The estrogen receptor has a variety of central physiological roles, including those involved in maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems. ER alpha has been shown to form homodimers as well as heterodimers with ER beta. Both ER alpha and ER beta can give rise to numerous isoforms.
Estrogen receptor antagonist
| Alternate Names: | Fulvestrant |
| Chemical Name: | 7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol |
| Purity: | ≥98% (HPLC) |
Potent and selective ERα Degrader (SNIPER)
| Chemical Name: | (2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide |
| Purity: | ≥98% (HPLC) |
Subtype-selective ERα agonist
| Chemical Name: | 4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol |
| Purity: | ≥98% (HPLC) |
Potent subtype-selective ligand; ERα agonist/ERβ antagonist
| Chemical Name: | (R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol |
| Purity: | ≥98% (HPLC) |
Highly selective ERα antagonist
| Chemical Name: | 1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride |
| Purity: | ≥98% (HPLC) |
Selective estrogen receptor modulator (SERM), selective for ERα
| Chemical Name: | [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]methanone |
| Purity: | ≥98% (HPLC) |
Estrogen receptor partial agonist/antagonist
| Chemical Name: | 2-[4-[(1Z)-1,2-Diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylethanamine |
| Purity: | ≥98% (HPLC) |
Metabolite of tamoxifen (Cat. No. 0999)
| Alternate Names: | 4-OH-TAM |
| Chemical Name: | 4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol |
| Purity: | ≥98% (HPLC) |
Estrogen receptor partial agonist/antagonist
| Chemical Name: | (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate |
| Purity: | ≥98% (HPLC) |
Selective estrogen receptor modulator (SERM)
| Alternate Names: | LY 139481,Keoxifene |
| Chemical Name: | [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone hydrochloride |
| Purity: | ≥98% (HPLC) |
EGFR kinase inhibitor. Also estrogen and PPARγ ligand
| Chemical Name: | 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% (HPLC) |
ERα antagonist; also activates unfolded protein response; active in vivo
| Chemical Name: | 1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one |
| Purity: | ≥98% (HPLC) |
