Raloxifene hydrochloride

Name: Raloxifene hydrochloride
Brand: Tocris Bioscience
SKU: 2280

Tocris Bioscience, part of Bio-Techne | Catalog # 2280

Citations (15)

COA / SDS

Selective estrogen receptor modulator (SERM)

Key Product Details

Description:	Selective estrogen receptor modulator (SERM)
Alternative Names:	LY 139481,Keoxifene
Chemical Name:	[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	510.04

View Full Technical Details for Raloxifene hydrochloride

Technical Data
Citations

Biological Activity for Raloxifene hydrochloride

Raloxifene hydrochloride is a selective estrogen receptor modulator (SERM) that binds to ERα and ERβ, and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC₅₀ of 1 nM.

Compound Libraries for Raloxifene hydrochloride

Raloxifene hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Raloxifene hydrochloride

M. Wt	510.04
Formula	C₂₈H₂₇NO₄S.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	82640-04-8
PubChem ID	54900
InChi Key	BKXVVCILCIUCLG-UHFFFAOYSA-N
Smiles	Cl.OC1=CC=C(C=C1)C1=C(C(=O)C2=CC=C(OCCN3CCCCC3)C=C2)C2=CC=C(O)C=C2S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Raloxifene hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.5	50

Preparing Stock Solutions for Raloxifene hydrochloride

The following data is based on the product molecular weight 510.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.92 mL	19.61 mL	39.21 mL
2.5 mM	0.78 mL	3.92 mL	7.84 mL
5 mM	0.39 mL	1.96 mL	3.92 mL
25 mM	0.08 mL	0.39 mL	0.78 mL

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References for Raloxifene hydrochloride

References are publications that support the biological activity of the product.

Todorova Tamoxifen and ralox. suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer Chemother. Pharmacol. 2011 PMID: 20383709
Bryant Mechanism of action and preclinical profile of raloxifene, a selective estrogen receptor modulator. Rev.Endocr.Metab.Disord. 2001 PMID: 11704975
Hibner Effects of ralox. hydrochloride on endometrial cancer cells in vitro. Gynecologic Oncol.
Fitzpatrick Effect of estrogen agonists and antagonists on induction of progesterone receptor in a rat hypothalamic cell line. Endocrinology 1999 PMID: 10465261