Raloxifene hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 2280

Selective estrogen receptor modulator (SERM)
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Key Product Details

Description

Selective estrogen receptor modulator (SERM)

Alternative Names

LY 139481,Keoxifene

View all Estrogen and Related Receptor Modulators »

Product Description

Raloxifene hydrochloride is a selective estrogen receptor modulator (SERM) that binds to ERα and ERβ, and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC50 of 1 nM.

Product Specifications

Molecular Weight

510.04

Formula

C28H27NO4S.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone hydrochloride

CAS Number

82640-04-8

PubChem ID

54900

InChI Key

BKXVVCILCIUCLG-UHFFFAOYSA-N

SMILES

Cl.OC1=CC=C(C=C1)C1=C(C(=O)C2=CC=C(OCCN3CCCCC3)C=C2)C2=CC=C(O)C=C2S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.5 50

Preparing Stock Solutions for Raloxifene hydrochloride

The following data is based on the product molecular weight 510.04

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.92 mL 19.61 mL 39.21 mL
2.5 mM 0.78 mL 3.92 mL 7.84 mL
5 mM 0.39 mL 1.96 mL 3.92 mL
25 mM 0.08 mL 0.39 mL 0.78 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Raloxifene hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Raloxifene hydrochloride

For research use only

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