(R,R)-THC
Tocris Bioscience, part of Bio-Techne | Catalog # 1990
Potent subtype-selective ligand; ERα agonist/ERβ antagonist
Key Product Details
Description
Potent subtype-selective ligand; ERα agonist/ERβ antagonist
Product Description
(R,R)-THC is a non-steroidal, selective estrogen receptor ligand. (R,R)-THC is an agonist at ERα receptor (Ki = 9.0 nM) and antagonist at ERβ receptor (Ki = 3.6 nM).Product Specifications
Molecular Weight
320.42
Formula
C22H24O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol
CAS Number
138090-06-9
PubChem ID
446849
InChI Key
MASYAWHPJCQLSW-ZIAGYGMSSA-N
SMILES
OC3=CC=C(C(C[C@H]4CC)=C3)C2=C4C1=CC=C(O)C=C1C[C@H]2CC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.04 | 100 | |
| Ethanol | 32.04 | 100 |
Preparing Stock Solutions
for (R,R)-THC
The following data is based on the product molecular weight 320.42
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.12 mL | 15.60 mL | 31.21 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kraichely Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-α and estrogen receptor-β: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology 2000 PMID: 11014206
- Meyers Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11, 12-tetrahydrochrysenes. J.Med.Chem. 1999 PMID: 10395487
- Sun Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-α or estrogen receptor-β. Endocrinology 1999 PMID: 9927308
Product Specific Notices for (R,R)-THC
For research use only
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