Coronavirus Antiviral Compounds Small Molecules and Peptides

DNA synthesis inhibitor

Calcineurin inhibitor

Potent inhibitor of SERCA ATPase

mTOR inhibitor; immunosuppressant

Activator of LKB1/AMPK; antidiabetic agent

Na+/K+ ATPase inhibitor

STAT3 inhibitor; also inhibits mTORC1 signaling

Inhibitor of protein synthesis

Histone deacetylase inhibitor

Antimalarial; inhibits apoptosis and autophagy

Potent and selective BET bromodomain inhibitor; cell permeable

MRP and OAT3 inhibitor

Highly potent pan-Src/Bcr-Abl inhibitor

Cyclooxygenase inhibitor (COX-1 > COX-2)

Potent calcineurin inhibitor; immunosuppressant

Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities

Cathepsin inhibitor; interferes with autolysosomal digestion

Antimicrobial peptide derivative of human cathelicidin

Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

Potent and selective JAK1/JAK2 inhibitor; orally bioavailable

Non-selective PI 3-kinase inhibitor

PPARα antagonist

Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide prodrug

DNA topoisomerase II inhibitor

DNA topoisomerase II inhibitor