Remdesivir

Name: Remdesivir
Brand: Tocris Bioscience
SKU: 7226

Tocris Bioscience a Bio-Techne Brand

Catalog # 7226

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Key Product Details

Description:	Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide prodrug
Alternative Names:	GS-5734
Chemical Name:	2-Ethylbutyl (2S)-2-[[(S)-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate
Purity:	≥98% (HPLC)
Molecular Weight:	602.58

View Full Technical Details for Remdesivir

Biological Activity for Remdesivir

Remdesivir is a viral RNA-dependent RNA polymerase inhibitor (RdRp) and broad spectrum antiviral nucleotide prodrug. Metabolized to active form, GS 441524 (Cat. No. 7227). Exhibits activity against a range of RNA viruses in vitro (EC₅₀ values are 0.019, 0.07, 0.07 - 0.34, 0.086 - 0.14, and 23.15 μM against RSV, SARS-CoV, MERS-CoV, EBOV and SARS-CoV-2, respectively). Exhibits antiviral efficacy in animal models of MERS-CoV and EBOV infection.

Compound Libraries for Remdesivir

Remdesivir is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Remdesivir

M. Wt	602.58
Formula	C₂₇H₃₅N₆O₈P
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1809249-37-3
PubChem ID	121304016
InChi Key	RWWYLEGWBNMMLJ-YSOARWBDSA-N
Smiles	CCC(COC([C@@H](N[P@](OC[C@H]1O[C@]([C@@H]([C@@H]1O)O)(C2=CC=C3N2N=CN=C3N)C#N)(OC4=CC=CC=C4)=O)C)=O)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Remdesivir

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	60.26	100
	ethanol	12.05	20

Preparing Stock Solutions for Remdesivir

The following data is based on the product molecular weight 602.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.66 mL	8.30 mL	16.60 mL
5 mM	0.33 mL	1.66 mL	3.32 mL
10 mM	0.17 mL	0.83 mL	1.66 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

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Reconstitution Calculator

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References for Remdesivir

References are publications that support the biological activity of the product.

Sheahan Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat.Commun. 2020 PMID: 31924756
Choy Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2replication in vitro. Antiviral Res. 2020 PMID: 32251767
Warren Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature 2016 PMID: 26934220

Citations for Remdesivir

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