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10 results for "Checkpoint Control Kinase Inhibitors" in Products

Checkpoint Control Kinase Inhibitors Products

Checkpoint control kinases is a term used to describe a group of enzymes that regulate progression of a cell through the cell cycle. Catastrophic genetic damage can occur if cells progress to the next phase of the cell cycle before the previous phase is properly completed. Checkpoint control kinases function to halt the cell cycle at these critical points. Examples of checkpoint control kinases include ATM, ATR, DNA-PK, Chk1, Chk2, Wee1 and mTOR.

For a cell to progress through the cycle and ...

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Potent and selective ATM kinase inhibitor

Chemical Name: 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one
Purity: ≥98% (HPLC)
Potent and selective ATM kinase inhibitor

Potent and selective BUB1 kinase inhibitor

Chemical Name: 2-[3,5-Difluoro-4-[[3-[5-methoxy-4-[(3-methoxy-4-pyridinyl)amino]-2-pyrimidinyl]-1H-indazol-1-yl]methyl]phenoxy]ethanol
Purity: ≥98% (HPLC)
Potent and selective BUB1 kinase inhibitor

Potent and selective Mps1 kinase inhibitor

Chemical Name: 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
Purity: ≥98% (HPLC)
Potent and selective Mps1 kinase inhibitor

Potent and selective DNA-PK inhibitor

Alternate Names: KU 57788
Chemical Name: 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Potent and selective DNA-PK inhibitor

MRN-ATM pathway inhibitor

Chemical Name: Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
Purity: ≥98% (HPLC)
MRN-ATM pathway inhibitor

Potent and selective Wee1 inhibitor

Alternate Names: AZD 1775,MK 1775
Chemical Name: 1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one
Purity: ≥98% (HPLC)
Potent and selective Wee1 inhibitor

Chk1 inhibitor

Chemical Name: 9,10,11,12-Tetrahydro- 9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione
Purity: ≥98% (HPLC)
Chk1 inhibitor

Potent and selective inhibitor of Chk1 and Wee1

Chemical Name: 9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Purity: ≥98% (HPLC)
Potent and selective inhibitor of Chk1 and Wee1

Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1

Chemical Name: 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride
Purity: ≥98% (HPLC)
Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1

Cdk inhibitor; potently inhibits cdk9; also inhibits MK2

Chemical Name: 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride
Purity: ≥98% (HPLC)
Cdk inhibitor; potently inhibits cdk9; also inhibits MK2
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