PD 166285 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3785
Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1
Key Product Details
Description
Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1
Product Description
PD 166285 dihydrochloride is a potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFRβ) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G2 checkpoint.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
585.35
Formula
C26H27Cl2N5O2.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride
CAS Number
212391-63-4
PubChem ID
9916391
InChI Key
NADLBPWBFGTESN-UHFFFAOYSA-N
SMILES
CN(C1=NC(NC4=CC=C(OCCN(CC)CC)C=C4)=NC=C1C=C2C3=C(Cl)C=CC=C3Cl)C2=O.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.53 | 100 |
Preparing Stock Solutions
for PD 166285 dihydrochloride
The following data is based on the product molecular weight 585.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.71 mL | 8.54 mL | 17.08 mL |
| 5 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 10 mM | 0.17 mL | 0.85 mL | 1.71 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang Radiosensitization of p53 mutant cells by PD0166285, a novel G2 checkpoint abrogator. Cancer Res. 2001 PMID: 11719452
- Hashimoto Cell cycle regulation by the Wee1 inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line. BMC Cancer 2006 PMID: 17177986
- Panek In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor. J.Pharmacol.Exp.Ther. 1997 PMID: 9400019
Product Specific Notices for PD 166285 dihydrochloride
For research use only
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