AZ 3146

Tocris Bioscience, part of Bio-Techne | Catalog # 3994

Potent and selective Mps1 kinase inhibitor
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Key Product Details

Description

Potent and selective Mps1 kinase inhibitor

View all TTK/Mps1 Kinase Inhibitors »

Product Description

AZ 3146 is a potent and selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 35 nM). Displays selectivity over 46 other kinases including Cdk1 and aurora kinase B. Interferes with chromosome alignment and overrides spindle assembly checkpoint. Inhibits the recruitment of Mad1, Mad2 and centromere protein E (CENP-E) to kinetochores.

Licensing Information

Sold for research purposes only under agreement from AstraZeneca UK Ltd.

Product Specifications

Molecular Weight

452.55

Formula

C24H32N6O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

CAS Number

1124329-14-1

PubChem ID

56973724

InChI Key

YUKWVHPTFRQHMF-UHFFFAOYSA-N

SMILES

CN(C1=CN=C(NC4=CC=C(OC5CCN(C)CC5)C=C4OC)N=C1N2C3CCCC3)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.31 25
Ethanol 33.94 75

Preparing Stock Solutions for AZ 3146

The following data is based on the product molecular weight 452.55

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 2.95 mL 14.73 mL 29.46 mL
3.75 mM 0.59 mL 2.95 mL 5.89 mL
7.5 mM 0.29 mL 1.47 mL 2.95 mL
37.5 mM 0.06 mL 0.29 mL 0.59 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for AZ 3146

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AZ 3146

For research use only

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