Mirin
Tocris Bioscience, part of Bio-Techne | Catalog # 3190
MRN-ATM pathway inhibitor
Key Product Details
Description
MRN-ATM pathway inhibitor
Product Description
Mirin is a Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50 = 12 μM) and induces G2 cell cycle arrest. Also blocks homology-directed repair in vitro.Product Specifications
Molecular Weight
220.25
Formula
C10H8N2O2S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
CAS Number
1198097-97-0
PubChem ID
1206243
InChI Key
YBHQCJILTOVLHD-YVMONPNESA-N
SMILES
OC(C=C1)=CC=C1/C=C2/C(NC(S2)=N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.02 | 100 |
Preparing Stock Solutions
for Mirin
The following data is based on the product molecular weight 220.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.54 mL | 22.70 mL | 45.40 mL |
| 5 mM | 0.91 mL | 4.54 mL | 9.08 mL |
| 10 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.91 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Stivers Small molecule versus DNA repair mechanisms. Nat.Chem.Biol. 2008 PMID: 18202674
- Garner Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 2009 PMID: 19219009
- Dupre A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 2008 PMID: 18176557
Product Specific Notices for Mirin
For research use only
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