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VHL Small Molecules and Peptides

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

cis MZ 1

Catalog #: 6155

Product Documents

Images (1)

Negative Control for MZ 1 (Cat. No. 6154)

Chemical Name:

(2S,4S)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity:

≥98%

VH 032 amide-alkylC2-amine

Catalog #: 6852

Product Documents

Images (1)

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-C2-NH₂

Chemical Name:

(2S,4R)-1-((S)-2-(3-Aminopropanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032 amide-PEG2-amine

Catalog #: 6907

Product Documents

Images (1)

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-PEG2-NH₂

Chemical Name:

(2S,4R)-1-((S)-2-(2-(2-(2-Aminoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity:

≥95%

VH 032 amide-alkylC2-acid

Catalog #: 7106

Product Documents

Images (1)

VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names:

(S,R,S)-AHPC-C2-COOH

Chemical Name:

4-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid

Purity:

≥95%

VH 101 phenol-alkylC4-amine

Catalog #: 7293

Product Documents

Images (1)

VHL ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name:

(2S,4R)-N-(2-(4-Aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 101 phenol-alkylC6-amine

Catalog #: 7294

Product Documents

Images (1)

VHL ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name:

(2S,4R)-N-(2-((6-Aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032, amine

Catalog #: 6462

Product Documents

Images (1)

Functionalized VHL ligand for PROTACs

Chemical Name:

(4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride

Purity:

≥98%

VH 032 amide-PEG3-amine

Catalog #: 6463

Product Documents

Images (1)

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-PEG3-NH₂

Chemical Name:

(2S,4R)-1-((S)-14-amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032 amide-PEG4-amine

Catalog #: 6464

(1)

Product Documents

Images (1)

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-PEG4-NH₂

Chemical Name:

(2S,4R)-1-((S)-17-Amino-2-(tert-butyl)-4-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032 amide-alkylC4-amine

Catalog #: 6465

(1)

Product Documents

Images (1)

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-C4-NH₂

Chemical Name:

(2S,4R)-1-((S)-2-(5-aminopentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032 amide-alkylC4-acid

Catalog #: 6680

Product Documents

Images (1)

VHL ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names:

(S,R,S)-AHPC-C4-COOH

Chemical Name:

6-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-6-oxohexanoic acid

Purity:

≥95%

VH 032, propargyl

Catalog #: 6683

Product Documents

Images (1)

Alkyne-functionalized VH 032; 'click' VHL ligand for PROTACs

Chemical Name:

(2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(prop-2-yn-1-yloxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity:

≥95%

VH 032 amide-alkylC6-amine

Catalog #: 6853

Product Documents

Images (1)

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:

VH 032 - linker 8,(_S,R,S)-AHPC-C2-NH₂

Chemical Name:

(2S,4R)-1-((S)-2-(7-Aminoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032 amide-PEG1-amine

Catalog #: 6879

(1)

Product Documents

Images (1)

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-PEG1-NH₂

Chemical Name:

(2S,4R)-1-((S)-2-(2-(2-Aminoethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032 amide-alkylC10-amine

Catalog #: 6880

Product Documents

Images (1)

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-C10-NH₂

Chemical Name:

(2S,4R)-1-((S)-2-(11-Aminoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032 phenol-alkylC4-amine

Catalog #: 6909

Product Documents

Images (1)

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-phenol-C4-NH2

Chemical Name:

(2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-N-(2-(4-aminobutoxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032 phenol-alkylC6-amine

Catalog #: 6910

Product Documents

Images (1)

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-phenol-C6-NH₂

Chemical Name:

(2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-N-(2-((6-aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032, phenol

Catalog #: 6911

Product Documents

Images (1)

Hydroxyl functionalized VHL ligand

Alternate Names:

(S,R,S)-AHPC-phenol

Chemical Name:

(2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity:

≥98%

VH 101, phenol

Catalog #: 6952

Product Documents

Images (1)

Hydroxyl functionalized VHL ligand

Chemical Name:

(2S,4R)-1-((S)-2-(1-Fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity:

≥98%

cis VH 032, amine dihydrochloride

Catalog #: 6969

Product Documents

Images (1)

Negative control for VH 032, amine (Cat. No. 6462)

Alternate Names:

(S,S,S)-AHPC

Chemical Name:

(2S,4S)-1-[(2S)-2-Amino-3,3-dimethyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide dihydrochloride

Purity:

≥98%

VH 032 amide-alkylC5-amine

Catalog #: 6985

Product Documents

Images (1)

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-C5-NH₂

Chemical Name:

(2S,4R)-1-((S)-2-(6-Aminohexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032 amide-alkylC3-amine

Catalog #: 7073

Product Documents

Images (1)

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-C3-NH₂

Chemical Name:

(2S,4R)-1-((S)-2-(4-Aminobutanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride

Purity:

≥95%

VH 032 amide-alkylC7-amine

Catalog #: 7074

Product Documents

Images (1)

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:

(S,R,S)-AHPC-C7-NH₂

Chemical Name:

(2S,4R)-1-((S)-2-(8-Aminooctanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

Purity:

≥95%

VH 032 amide-PEG1-acid

Catalog #: 7104

Product Documents

Images (1)

VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names:

(S,R,S)-AHPC-PEG1-COOH

Chemical Name:

3-(3-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propanoic acid

Purity:

≥95%

VH 032 amide-PEG1-acid

Catalog #: 7104

Product Documents

Images (1)

VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names:

(S,R,S)-AHPC-PEG1-COOH

Chemical Name:

3-(3-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propanoic acid

Purity:

≥95%

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