VH 032, phenol
Tocris Bioscience, part of Bio-Techne | Catalog # 6911
Hydroxyl functionalized VHL ligand
Key Product Details
Description
Hydroxyl functionalized VHL ligand
Alternative Names
(S,R,S)-AHPC-phenol
Product Description
VH 032, phenol is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand with terminal hydroxyl ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
488.60
Formula
C24H32N4O5S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS Number
2244684-42-0
PubChem ID
142452655
InChI Key
CUHVZPHLQIBKHX-LVCYWYKZSA-N
SMILES
CC1=C(C2=CC=C(C(O)=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(C)=O)=O)O)=O)SC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 48.86 | 100 | |
| DMSO | 48.86 | 100 |
Preparing Stock Solutions
for VH 032, phenol
The following data is based on the product molecular weight 488.60
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.05 mL | 10.23 mL | 20.47 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.09 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.05 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Maniaci Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat.Comm. 2017 PMID: 29018234
Product Specific Notices for VH 032, phenol
For research use only
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