VH 032, phenol

Name: VH 032, phenol
Brand: Tocris Bioscience
SKU: 6911

Tocris Bioscience, part of Bio-Techne | Catalog # 6911

Citations (1)

COA / SDS

Hydroxyl functionalized VHL ligand

Key Product Details

Description:	Hydroxyl functionalized VHL ligand
Alternative Names:	(S,R,S)-AHPC-phenol
Chemical Name:	(2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	488.6

View Full Technical Details for VH 032, phenol

Technical Data
Citations

Biological Activity for VH 032, phenol

VH 032, phenol is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC^® research and development; incorporates an E3 ligase ligand with terminal hydroxyl ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for VH 032, phenol

M. Wt	488.6
Formula	C₂₄H₃₂N₄O₅S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2244684-42-0
PubChem ID	142452655
InChi Key	CUHVZPHLQIBKHX-LVCYWYKZSA-N
Smiles	CC1=C(C2=CC=C(C(O)=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(C)=O)=O)O)=O)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for VH 032, phenol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	48.86	100
	DMF	48.86	100

Preparing Stock Solutions for VH 032, phenol

The following data is based on the product molecular weight 488.6.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.23 mL	20.47 mL
5 mM	0.41 mL	2.05 mL	4.09 mL
10 mM	0.20 mL	1.02 mL	2.05 mL
50 mM	0.04 mL	0.20 mL	0.41 mL

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Reconstitution Calculator

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References for VH 032, phenol

References are publications that support the biological activity of the product.

Maniaci Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat.Comm. 2017 PMID: 29018234