VEGF 121: Proteins and Enzymes

VEGF (Vascular endothelial growth factor) is the only growth factor that stimulates vascular permeability. It promotes endothelial proliferation and survival, angiogenesis, vasculognesis and inhibits apoptosis. VEGF mitogenic activity is specific for endothelial cell and that makes it distinct among other growth factors. VEGF is thought to be important in the pathophysiology of neuronal and other tumors, by functioning as a promter of angiogenesis for human gliomas. VEGF121 has increased acidity which allowes it to circulate more freely than other VEGF forms. Biological activities of VEGF are not species-specific and glycosylation is not required for biological activity.