t-Plasminogen Activator/tPA Products
tPA (tissue-type Plasminogen Activator) is a serine protease that is secreted by vascular endothelial cells, fibroblasts, neurons, microglia, and astrocytes. The partially active single chain can be further processed to full activity by Plasmin, Kallikrein 1, or Coagulation Factor Xa. Active tPA converts Plasminogen to Plasmin, a fibrinolytic protease, by hydrolyzing an Arg-Val peptide bond in Plasminogen.
Unusually high levels of tPA activity can result in excessive bleeding, and low levels of tPA activity can result in thrombosis or embolism. tPA-mediated breakdown of the extracellular is also involved in promoting synaptic plasticity, neurite outgrowth, and synapse remodeling. Human tPA contains an N-terminal fibronectin type-1 domain, an epidermal growth factor-like domain, two kringle domains, and a serine protease catalytic domain.
Products:
86 results for "t-Plasminogen Activator/tPA" in Products
86 results for "t-Plasminogen Activator/tPA" in Products
t-Plasminogen Activator/tPA Products
tPA (tissue-type Plasminogen Activator) is a serine protease that is secreted by vascular endothelial cells, fibroblasts, neurons, microglia, and astrocytes. The partially active single chain can be further processed to full activity by Plasmin, Kallikrein 1, or Coagulation Factor Xa. Active tPA converts Plasminogen to Plasmin, a fibrinolytic protease, by hydrolyzing an Arg-Val peptide bond in Plasminogen.
Unusually high levels of tPA activity can result in excessive bleeding, and low levels of tPA activity can result in thrombosis or embolism. tPA-mediated breakdown of the extracellular is also involved in promoting synaptic plasticity, neurite outgrowth, and synapse remodeling. Human tPA contains an N-terminal fibronectin type-1 domain, an epidermal growth factor-like domain, two kringle domains, and a serine protease catalytic domain.
Products:
| Sensitivity: | 16.1 pg/mL |
| Applications: | ELISA |
| Assay Range: | 78.1 - 5,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma, Saliva, Urine, Human Milk) |
| Source: | CHO |
| Accession #: | P00750 |
| Applications: | EnzAct |
| Assay Range: | 78.1 - 5,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA |
![Western Blot: t-Plasminogen Activator/tPA Antibody [NBP2-20648]](https://resources.bio-techne.com/images/products/t-Plasminogen-Activator-tPA-Antibody-Western-Blot-NBP2-20648-img0019.jpg "Western Blot: t-Plasminogen Activator/tPA Antibody [NBP2-20648]")
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #OTI3H3 |
| Applications: | IHC, WB |
![Western Blot: t-Plasminogen Activator/tPA Antibody (OTI3H3) [NBP2-46435]](https://resources.bio-techne.com/images/products/t-Plasminogen-Activator-tPA-Antibody-3H3-Western-Blot-NBP2-46435-img0007.jpg "Western Blot: t-Plasminogen Activator/tPA Antibody (OTI3H3) [NBP2-46435]")
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #OTI3H3 |
| Applications: | IHC, WB |
![Western Blot: t-Plasminogen Activator/tPA Antibody (OTI3H3)Azide and BSA Free [NBP2-74568]](https://resources.bio-techne.com/images/products/t-Plasminogen-Activator-tPA-Antibody-OTI3H3-Azide-and-BSA-Free-Western-Blot-NBP2-74568-img0001.jpg "Western Blot: t-Plasminogen Activator/tPA Antibody (OTI3H3)Azide and BSA Free [NBP2-74568]")
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB |
| Applications: | Func |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #10W4L1 |
| Applications: | WB, ELISA, ICC/IF |
![Western Blot: t-Plasminogen Activator/tPA Antibody (10W4L1) [NBP3-16356]](https://resources.bio-techne.com/images/products/t-Plasminogen-Activator-tPA-Antibody-10W4L1-Western-Blot-NBP3-16356-img0002.jpg "Western Blot: t-Plasminogen Activator/tPA Antibody (10W4L1) [NBP3-16356]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: t-Plasminogen Activator/tPA Antibody [NBP1-87491]](https://resources.bio-techne.com/images/products/t-Plasminogen-Activator-tPA-Antibody-Immunohistochemistry-Paraffin-NBP1-87491-img0007.jpg "Immunohistochemistry-Paraffin: t-Plasminogen Activator/tPA Antibody [NBP1-87491]")
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #K17 |
| Applications: | WB, ICC/IF |
| Reactivity: | Human, Rat, Porcine |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #K12 |
| Applications: | WB |
| Applications: | WB |
![Western Blot: t-Plasminogen Activator/tPA Overexpression Lysate [NBL1-14484]](https://resources.bio-techne.com/images/products/Tissue-Plasminogen-Activator-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-14484-img0002.jpg "Western Blot: t-Plasminogen Activator/tPA Overexpression Lysate [NBL1-14484]")
| Applications: | WB |
![Western Blot: t-Plasminogen Activator/tPA Overexpression Lysate [NBL1-14485]](https://resources.bio-techne.com/images/products/Tissue-Plasminogen-Activator-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-14485-img0002.jpg "Western Blot: t-Plasminogen Activator/tPA Overexpression Lysate [NBL1-14485]")
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #32B1 |
| Applications: | ELISA, Flow |
| Applications: | PAGE |
![SDS-PAGE: Recombinant Human t-Plasminogen Activator/tPA His Protein [NBP2-59553]](https://resources.bio-techne.com/images/products/Recombinant-Human-t-Plasminogen-Activator-tPA-Protein-SDS-Page-NBP2-59553-img0001.jpg "SDS-PAGE: Recombinant Human t-Plasminogen Activator/tPA His Protein [NBP2-59553]")