8 results for "Protein Arginine Methyltransferase Inhibitors Small Molecules and Peptides" in Products
Protein Arginine Methyltransferase Inhibitors: Small Molecules and Peptides
Protein Arginine methyltransferases, or PRMTs, are a family of enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to arginine residues on histones. PRMTs belong to the histone methyltransferase group of enzymes, which also includes lysine methyltransferases. They are also closely related in biological activity to the DNA methyltransferases and are ubiquitously expressed. Histone methylation of arginine residues occurs predominantly on histones H2A, H3 and H4, ...
Potent and selective PRMT 4 inhibitor
| Chemical Name: | N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide |
| Purity: | ≥98% (HPLC) |
Potent and selective type I PRMT inhibitor
| Chemical Name: | N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective PRMT5 inhibitor
| Chemical Name: | N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective PRMT6 allosteric inhibitor
| Chemical Name: | (R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one |
| Purity: | ≥98% (HPLC) |
Potent and selective allosteric inhibitor of PRMT3
| Chemical Name: | 1-(Isoquinolin-6-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl] urea |
| Purity: | ≥98% (HPLC) |
Negative control of SGC 707 (Cat. No. 5367)
| Chemical Name: | N-2-Naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea |
| Purity: | ≥98% (HPLC) |
Selective PRMT5 Degrader (PROTAC®)
| Chemical Name: | N-((S)-3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-((S)-19-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoyl)azetidin-3-yl)amino)pyrimidine-4-carboxamide |
| Purity: | ≥98% (HPLC) |
Negative control for SGC 6870 (Cat. No. 7182)
| Chemical Name: | (S)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one |
| Purity: | ≥98% (HPLC) |
