MS 023 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5713
Potent and selective type I PRMT inhibitor
Key Product Details
Description
Potent and selective type I PRMT inhibitor
Product Description
MS 023 dihydrochloride is a potent and selective type I PRMT inhibitor (IC50 values are 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Exhibits no significant activity against type II and III PRMTs, PKMTs, DNMTs, KDMs and reader proteins. Reduces global arginine asymmetric dimethylation levels in vitro. Also inhibits and reduces TGF-β-activated kinase 1 expression and protein levels.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MS023 probe summary on the SGC website.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MS023 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
360.32
Formula
C17H25N3O.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride
CAS Number
1992047-64-9
PubChem ID
121513886
InChI Key
HCNXCUFNZWGILO-UHFFFAOYSA-N
SMILES
CC(C)OC1=CC=C(C2=CNC=C2CN(CCN)C)C=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 36.03 | 100 | |
| DMSO | 36.03 | 100 |
Preparing Stock Solutions
for MS 023 dihydrochloride
The following data is based on the product molecular weight 360.32
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.78 mL | 13.88 mL | 27.75 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.55 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.78 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Scheer A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 2019 PMID: 30604761
- Eram A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases. ACS Chem.Biol. 2016 PMID: 26598975
Product Specific Notices for MS 023 dihydrochloride
For research use only
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