Furamidine dihydrochloride

Product Description

Furamidine dihydrochloride is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 9.4 μM). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC₅₀ values are 166, 283 and >400 μM respectively). Inhibits tyrosyl-DNA phosphodiesterase 1 (TDP-1) (IC₅₀ = 1.2 μM). Inhibits cell proliferation in leukemia cell lines, suppresses neuroblastoma tumor growth, and reduces mis-splicing in in vitro and in vivo models of myotonic dystrophy type 1. Also shows dose-dependent inhibition of platelet aggregation (IC50 = 14.8 uM). Cell-permeable.

Solubility

Preparing Stock Solutions for Furamidine dihydrochloride

The following data is based on the product molecular weight 377.27

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.30 mL	26.51 mL	53.01 mL
2.5 mM	1.06 mL	5.30 mL	10.60 mL
5 mM	0.53 mL	2.65 mL	5.30 mL
25 mM	0.11 mL	0.53 mL	1.06 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Marsden Inhibition of arginine methylation impairs platelet function. ACS Pharmacol.Transl.Sci. 2021 PMID: 34661075
• Jenquin Furamidine rescues myotonic dystrophy type I associated mis-splicing through multiple mechanisms. ACS Chem.Biol. 2018 PMID: 30118588
• Hua PRMT1 promotes neuroblastoma cell survival through ATF5. Oncogenesis 2020 PMID: 32415090
• Yan Diamidine compounds for selective inhibition of protein arginine methyltransferase 1. J.Med.Chem. 2014 PMID: 24564570