SGC 6870

Name: SGC 6870
Brand: Tocris Bioscience
SKU: 7182

Tocris Bioscience, part of Bio-Techne | Catalog # 7182

COA / SDS

Potent and selective PRMT6 allosteric inhibitor

Key Product Details

Description:	Potent and selective PRMT6 allosteric inhibitor
Chemical Name:	(R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one
Purity:	≥98% (HPLC)
Molecular Weight:	469.4

View Full Technical Details for SGC 6870

Technical Data
Citations

Biological Activity for SGC 6870

SGC 6870 is a potent and selective protein arginine methyltransferase 6 (PRMT6) allosteric inhibitor (IC₅₀ = 77 nM). Exhibits selectivity over all other PRMTs and 23 methyltransferases. In HEK293T cells overexpressing PRMT6, inhibits asymmetric dimethylation of H3R2 (IC₅₀ = 0.8 μM)

Negative control SGC 6870N (Cat. No. 7184) also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 6870 probe summary on the SGC website.

Compound Libraries for SGC 6870

SGC 6870 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for SGC 6870

M. Wt	469.4
Formula	C₂₃H₂₁BrN₂O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2561471-27-8
PubChem ID	146026048
InChi Key	NIPTUMFVYBXSMZ-JOCHJYFZSA-N
Smiles	CC1=CC=C2C([C@@H](C3=CC(C)=CC(C)=C3)N(C(C4=CC=C(Br)S4)=O)CC(N2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SGC 6870

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.94	100
	ethanol	46.94	100

Preparing Stock Solutions for SGC 6870

The following data is based on the product molecular weight 469.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.65 mL	21.30 mL
5 mM	0.43 mL	2.13 mL	4.26 mL
10 mM	0.21 mL	1.07 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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Reconstitution Calculator

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References for SGC 6870

References are publications that support the biological activity of the product.

Shen A first-in-class, highly selective and cell-active allosteric inhibitor of protein arginine methyltransferase 6 (PRMT6) J.Med.Chem. 2021 PMID: 33591753