14 results for "p38 alpha Small Molecules and Peptides" in Products
p38 alpha: Small Molecules and Peptides
The p38 Mitogen-activated Protein Kinases (MAPKs) are a family of four related Ser/Thr kinases activated by proinflammatory cytokines and environmental stresses. All four p38 family members, alpha, beta, gamma, and delta, are phosphorylated by MKK3 and/or MKK6 at dual Thr and Tyr positions within the phosphoacceptor sequence Thr-Gly-Tyr. Once activated, p38 phosphorylates a number of targets, including the nuclear transcription factors ATF2 and Max.
The most frequently analyzed family ...
Potent, selective inhibitor of p38 MAPK
| Chemical Name: | 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol |
| Purity: | ≥99% (HPLC) |
Selective inhibitor of p38 MAPK
| Alternate Names: | Adezmapimod |
| Chemical Name: | 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine |
| Purity: | ≥98% (HPLC) |
High affinity and selective p38 kinase inhibitor
| Alternate Names: | Doramapimod |
| Chemical Name: | N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of p38α and p38β2
| Chemical Name: | (2-Methylphenyl)-[4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl]methanone |
| Purity: | ≥98% (HPLC) |
Potent and selective p38α and p38β Degrader (PROTAC®); active in vivo
| Chemical Name: | 3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N-(4-(1-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)amino)-4-oxobutyl)-1H-1,2,3-triazol-4-yl)butyl)-4-methylbenzamide |
| Purity: | ≥97% (HPLC) |
Potent and selective p38α inhibitor
| Alternate Names: | VX745,VX-745,Neflamapimod |
| Chemical Name: | 5-(2,6-Dichlorophenyl)-2-[2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one |
| Purity: | ≥98% (HPLC) |
p38 MAPK inhibitor
| Chemical Name: | N-Cyano-N'-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7,8-dihydro-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]guanidine |
| Purity: | ≥98% (HPLC) |
Selective inhibitor of p38 MAPK; water-soluble
| Chemical Name: | 4-[5-(4-Fluorophenyl)-2-[4-(methylsulphonyl)phenyl]-1H-imidazol-4-yl]pyridine hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective p38 MAPK inhibitor
| Chemical Name: | 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-1H-Indole-3-acetamide hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective p38α PROTAC®
| Alternate Names: | SJFa PROTAC,SJFalpha PROTAC,SJFα PROTAC |
| Chemical Name: | N-(3-Fluoro-4-((7-(4-(4-(2-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)butoxy)butoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide |
| Purity: | ≥98% (HPLC) |
Potent, selective p38α and p38β inhibitor
| Chemical Name: | 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol |
| Purity: | ≥98% (HPLC) |
p38 MAPK inhibitor; anti-inflammatory
| Chemical Name: | N-Cyclopropyl-4-[4-(4-fluorophenyl)-2-(4-piperidinyl)-5-thiazolyl]-2-pyrimidinamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective p38α/β inhibitor
| Chemical Name: | (-)-3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethylbenzamide |
| Purity: | ≥98% (HPLC) |
Potent p38 MAPK inhibitor; anti-inflammatory
| Chemical Name: | N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide |
| Purity: | ≥98% (HPLC) |
