EO 1428

Name: EO 1428
Brand: Tocris Bioscience
SKU: 2908

Tocris Bioscience, part of Bio-Techne | Catalog # 2908

Citations (5)

COA / SDS

Selective inhibitor of p38α and p38β2

Key Product Details

Description:	Selective inhibitor of p38α and p38β₂
Chemical Name:	(2-Methylphenyl)-[4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl]methanone
Purity:	≥98% (HPLC)
Molecular Weight:	415.71

View Full Technical Details for EO 1428

Technical Data
Citations

Biological Activity for EO 1428

EO 1428 is a selective inhibitor of p38α and p38β₂ that displays no activity at p38γ, p38δ, ERK1/2 and JNK1. Inhibits production of inflammatory cytokines including IL-8, TNF-α, IL-6, IL-1β and IL-10 (IC₅₀ values are 4, 5, 17, 30 and 74 nM respectively). Displays anti-inflammatory activity in murine models of acute and chronic dermatitis.

Compound Libraries for EO 1428

EO 1428 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for EO 1428

M. Wt	415.71
Formula	C₂₀H₁₆BrClN₂O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	321351-00-2
PubChem ID	9801969
InChi Key	HDCLCHNAEZNGNV-UHFFFAOYSA-N
Smiles	CC1=CC=CC=C1C(C2=CC=C(NC3=C(N)C=C(Br)C=C3)C=C2Cl)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for EO 1428

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.57	100
	ethanol	20.79	50

Preparing Stock Solutions for EO 1428

The following data is based on the product molecular weight 415.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.03 mL	24.06 mL
5 mM	0.48 mL	2.41 mL	4.81 mL
10 mM	0.24 mL	1.20 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for EO 1428

References are publications that support the biological activity of the product.

Ottosen Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. J.Med.Chem. 2003 PMID: 14667219