TAK 715

Name: TAK 715
Brand: Tocris Bioscience
SKU: 4254

Tocris Bioscience, part of Bio-Techne | Catalog # 4254

Citations (13)

COA / SDS

Potent p38 MAPK inhibitor; anti-inflammatory

Key Product Details

Description:	Potent p38 MAPK inhibitor; anti-inflammatory
Chemical Name:	N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	399.51

View Full Technical Details for TAK 715

Technical Data
Citations

Biological Activity for TAK 715

TAK 715 is an inhibitor of p38 MAPK (IC₅₀ = 7.1 nM for p38 MAPKα). Also inhibits Wnt-3a-stimulated β-catenin signaling. Inhibits 22 kinases by more than 80%, including CK1δ/ε. Anti-inflammatory and anti-rheumatoid arthritis agent. Orally bioavailable.

Compound Libraries for TAK 715

TAK 715 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for TAK 715

M. Wt	399.51
Formula	C₂₄H₂₁N₃OS
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	303162-79-0
PubChem ID	90488922
InChi Key	BRYAJHADJWBFQY-UHFFFAOYSA-N
Smiles	CCC1=NC(C3=CC(C)=CC=C3)=C(C2=C(NC(C4=CC=CC=C4)=O)N=CC=C2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TAK 715

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.95	100
	ethanol	19.98	50

Preparing Stock Solutions for TAK 715

The following data is based on the product molecular weight 399.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.52 mL	25.03 mL
5 mM	0.50 mL	2.50 mL	5.01 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for TAK 715

References are publications that support the biological activity of the product.

Verkaar Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ε. Chem.Biol. 2011 PMID: 21513885
Miwatashi Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: discovery of N-[4-{2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent. J.Med.Chem. 2005 PMID: 16162000