SJFα
Tocris Bioscience, part of Bio-Techne | Catalog # 7268
Potent and selective p38α PROTAC®
Key Product Details
Description
Potent and selective p38α PROTAC®
Alternative Names
SJFa PROTAC,SJFalpha PROTAC,SJFα PROTAC
Product Description
SJFα is a potent and selective p38α PROTAC® Degrader (DC50 = 7.16 nM; Dmax = 97.4%). SJFα comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Displays significantly lower potency degradation at p38δ (DC50 = 299 nM). Exhibits no significant degradation of p38β, p38γ or related MAPKs, ERK1/2, or JNK1/2.p38γ antibodies validated for Simple Western™ (automated Western) instruments also available: Catalog # AF1347 and MAB1347.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
1120.28
Formula
C59H67F2N7O11S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(3-Fluoro-4-((7-(4-(4-(2-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)butoxy)butoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
CAS Number
2254609-27-1
PubChem ID
137628677
InChI Key
GXDYWQXTEYENEU-WFYKIECOSA-N
SMILES
COC1=CC2=C(N=CC=C2OC3=C(C=C(C=C3)NC(C4(C(NC5=CC=C(C=C5)F)=O)CC4)=O)F)C=C1OCCCCOCCCCOCC(N[C@@H](C(C)(C)C)C(N6C[C@@H](C[C@H]6C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 112.03 | 100 |
Preparing Stock Solutions
for SJFα
The following data is based on the product molecular weight 1120.28
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.89 mL | 4.46 mL | 8.93 mL |
| 5 mM | 0.18 mL | 0.89 mL | 1.79 mL |
| 10 mM | 0.09 mL | 0.45 mL | 0.89 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.18 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Smith Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat. Commun. 2019 PMID: 30631068
Product Specific Notices for SJFα
For research use only
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