mGluR8: Small Molecules and Peptides
The Group III metabotropic glutamate receptors include mGluR4, 6, 7 and 8. These 7-transmembrane glycoproteins are negatively coupled to adenylate cyclase and expressed presynaptically throughout the brain. MGluR8 shows pronounced expression in the dentate gyrus and CA3 regions of the hippocampus, and is thought to play a role in memory formation.
8 results for "mGluR8 Small Molecules and Peptides" in Products
8 results for "mGluR8 Small Molecules and Peptides" in Products
mGluR8: Small Molecules and Peptides
The Group III metabotropic glutamate receptors include mGluR4, 6, 7 and 8. These 7-transmembrane glycoproteins are negatively coupled to adenylate cyclase and expressed presynaptically throughout the brain. MGluR8 shows pronounced expression in the dentate gyrus and CA3 regions of the hippocampus, and is thought to play a role in memory formation.
Selective group III mGlu agonist
| Chemical Name: | L-(+)-2-Amino-4-phosphonobutyric acid |
| Purity: | ≥99% (HPLC) |
Active metabolite of oxcarbazepine (Cat. No. 3864)
| Alternate Names: | GP 47779 |
| Chemical Name: | 10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide |
| Purity: | ≥98% (HPLC) |
Potent and highly selective group II mGlu agonist
| Chemical Name: | (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid |
| Purity: | ≥98% (HPLC) |
Potent and selective mGlu8a agonist
| Alternate Names: | UBP 1109 |
| Chemical Name: | (S)-3,4-Dicarboxyphenylglycine |
| Purity: | ≥98% (HPLC) |
Potent group III mGlu antagonist
| Chemical Name: | (RS)-α-Cyclopropyl-4-phosphonophenylglycine |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of mGlu7 and mGlu8 receptors; also NK1 antagonist; brain penetrant
| Chemical Name: | 3-(2,3-Difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of group I mGlu receptors
| Chemical Name: | (9H-Xanthen-9-ylcarbonyl)-carbamic acid butyl ester |
| Purity: | ≥98% (HPLC) |
Selective positive allosteric modulator of group III mGlu receptors
| Alternate Names: | ML 396 |
| Chemical Name: | N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide |
| Purity: | ≥98% (HPLC) |
