(S)-3,4-DCPG
Tocris Bioscience, part of Bio-Techne | Catalog # 1302
Potent and selective mGlu8a agonist
Key Product Details
Description
Potent and selective mGlu8a agonist
Alternative Names
UBP 1109
Product Description
(S)-3,4-DCPG is a potent, selective mGlu8a agonist (EC50 = 31 nM). Displays > 100-fold selectivity over mGlu1-7 and displays little or no activity at NMDA and kainate receptors. Increases c-Fos expression in stress-related brain areas following systemic administration in mice in vivo. Also potent anticonvulsant in mice in vivo.Caged (S)-3,4-DCPG, Racemate and R-enantiomer also available.
Product Specifications
Molecular Weight
239.18
Formula
C10H9NO6
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(S)-3,4-Dicarboxyphenylglycine
CAS Number
201730-11-2
PubChem ID
16062593
InChI Key
IJVMOGKBEVRBPP-ZETCQYMHSA-N
SMILES
N[C@]([H])(C(O)=O)C1=CC(C(O)=O)=C(C(O)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 23.92 | 100 | |
| DMSO | 5.98 | 25 |
Preparing Stock Solutions
for (S)-3,4-DCPG
The following data is based on the product molecular weight 239.18
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.18 mL | 20.90 mL | 41.81 mL |
| 5 mM | 0.84 mL | 4.18 mL | 8.36 mL |
| 10 mM | 0.42 mL | 2.09 mL | 4.18 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thomas (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology 2001 PMID: 11166323
- Moldrich Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology 2001 PMID: 11311902
- Thomas Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur.J.Pharmacol. 1997 PMID: 9455991
- Linden Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice. Neuropharmacology 2003 PMID: 12907308
Product Specific Notices for (S)-3,4-DCPG
For research use only
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