IGF-II R/IGF2R Products
IGF-II R/IGF2R is a type I transmembrane glycoprotein that contains a 2,264 amino acid (aa) extracellular region, a 23 aa transmembrane segment segment and a 124 aa cytoplasmic tail. IGF2R regulates many diverse biological functions that range from intracellular trafficking to the internalization of extracellular factors and modulation of cellular responses. It delivers newly synthesized M6P-tagged lysosomal enzymes from the trans-golgi network to endosomes, and facilitates the clearance of extracellular lysosomal and matrix degrading enzymes by internalization into clathrin-coated vesicles and delivery into endosomes. With respect to IGF2 biology, It would appear that IGF2R is principally a regulator of local IGF2 levels, targeting IGF2 for destruction in lysosomes.
Products:
151 results for "IGF-II R/IGF2R" in Products
151 results for "IGF-II R/IGF2R" in Products
IGF-II R/IGF2R Products
IGF-II R/IGF2R is a type I transmembrane glycoprotein that contains a 2,264 amino acid (aa) extracellular region, a 23 aa transmembrane segment segment and a 124 aa cytoplasmic tail. IGF2R regulates many diverse biological functions that range from intracellular trafficking to the internalization of extracellular factors and modulation of cellular responses. It delivers newly synthesized M6P-tagged lysosomal enzymes from the trans-golgi network to endosomes, and facilitates the clearance of extracellular lysosomal and matrix degrading enzymes by internalization into clathrin-coated vesicles and delivery into endosomes. With respect to IGF2 biology, It would appear that IGF2R is principally a regulator of local IGF2 levels, targeting IGF2 for destruction in lysosomes.
Products:
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready, +1 More |
| Reactivity: | Human, Mouse, Rat, Bovine, Primate |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #2G11 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +2 More |
![Immunocytochemistry/ Immunofluorescence: IGF-II R/IGF2R Antibody (2G11) - BSA Free [NB300-514]](https://resources.bio-techne.com/images/products/IGF-II-R-IGF2R-Antibody-2G11-Immunocytochemistry-Immunofluorescence-NB300-514-img0014.jpg "Immunocytochemistry/ Immunofluorescence: IGF-II R/IGF2R Antibody (2G11) - BSA Free [NB300-514]")
| Source: | CHO |
| Accession #: | P11717.3 |
| Applications: | BA |
| Reactivity: | Human, Mouse, Rat, Bovine, Primate |
| Details: | Mouse IgG2a Kappa Monoclonal Clone #2G11 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +2 More |
![Immunocytochemistry/ Immunofluorescence: IGF-II R/IGF2R Antibody (2G11) - Azide and BSA Free [NBP2-80785]](https://resources.bio-techne.com/images/products/IGF-II-R-IGF2R-Antibody-2G11-Azide-and-BSA-Free-Immunocytochemistry-Immunofluorescence-NBP2-80785-img0004.jpg "Immunocytochemistry/ Immunofluorescence: IGF-II R/IGF2R Antibody (2G11) - Azide and BSA Free [NBP2-80785]")
| Source: | CHO |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #372604 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready, +1 More |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready, +1 More |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready, +1 More |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready, +1 More |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready, +1 More |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready, +1 More |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready, +1 More |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #372604 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #372604 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #372604 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #372616 |
| Assay Range: | 156 - 10,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready, +1 More |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #372616 |
| Applications: | ELISA(Cap), ELISA(Det) |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #372616 |
| Applications: | ELISA(Cap), ELISA(Det) |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #372604 |
| Applications: | WB, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #372616 |
| Applications: | ELISA(Cap), ELISA(Det) |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #372616 |
| Applications: | ELISA(Cap), ELISA(Det) |