245 results for "FKBP12" in Products
FKBP12 Products
FK506 binding protein, also called FKBP12 and FKBP1A, was originally characterized as a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues critical for proper folding of proteins. The macrolide immunosuppressants FK506 (Tacrolimus) and rapamycin bind to FKBP12 with high affinity, while the structurally related-compound cyclosporine binds with a much lower affinity. The binding of these drugs causes FKBP12 to become a potent inhibitor of calcineurin phosphatase activity and TOR kinase activity. Knockout mice lacking FKBP12 are morphologically normal, but develop cardiomyopathies that may be related to dysregulation of ryanodyne receptors.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #426227 |
| Applications: | WB, IHC |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #426227 |
| Applications: | WB, IHC |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #426227 |
| Applications: | WB, IHC |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #426227 |
| Applications: | WB, IHC |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #426227 |
| Applications: | WB, IHC |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #426227 |
| Applications: | WB, IHC |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #426227 |
| Applications: | WB, IHC |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #426227 |
| Applications: | WB, IHC |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #426227 |
| Applications: | WB, IHC |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #422513 |
| Applications: | WB |
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| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #1049713 |
| Applications: | WB, ICC |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #422513 |
| Applications: | WB |
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| Source: | E. coli |
| Accession #: | NP_000792 |
| Applications: | InhibAct |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #422513 |
| Applications: | WB |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #422513 |
| Applications: | WB |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #422513 |
| Applications: | WB |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #422513 |
| Applications: | WB |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #422513 |
| Applications: | WB |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #422513 |
| Applications: | WB |
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| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #1049713 |
| Applications: | WB, ICC |
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| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #1049713 |
| Applications: | WB, ICC |
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| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #1049713 |
| Applications: | WB, ICC |
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| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #1049713 |
| Applications: | WB, ICC |
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| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #1049713 |
| Applications: | WB, ICC |
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| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2B Monoclonal Clone #OTI3B3 |
| Applications: | IHC, WB, Flow |
![Western Blot: FKBP12 Antibody (OTI3B3) [NBP2-02093]](https://resources.bio-techne.com/images/products/FKBP12-Antibody-3B3-Western-Blot-NBP2-02093-img0002.jpg "Western Blot: FKBP12 Antibody (OTI3B3) [NBP2-02093]")
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