TRAM 1
Tocris Bioscience, part of Bio-Techne | Catalog # 8121
Chemical inducer of proximity for dTAG protein FKBPF36V and ecDHFR tags
Key Product Details
Description
Chemical inducer of proximity for dTAG protein FKBPF36V and ecDHFR tags
Product Description
TRAM 1 is a targeted relocalization activating molecule (TRAM) and chemical inducer of proximity for the dTAG protein FKBP12F36V and ecDHFR tags. Can be used to shuttle and redistribute proteins in live cells.Product Specifications
Molecular Weight
1009.17
Formula
C54H68N6O13
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(R)-1-(3-(2-((3-(4-((2,4-Diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)amino)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
InChI Key
SGECTVFBOKCZAI-YZBUDRBASA-N
SMILES
O=C(O[C@H](CCC1=CC(OC)=C(C=C1)OC)C2=CC(OCC(NCCCOC3=C(C=C(C=C3OC)CC4=CN=C(N=C4N)N)OC)=O)=CC=C2)[C@@H]5CCCCN5C([C@@H](CC)C6=CC(OC)=C(C(OC)=C6)OC)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100.92 | 100 |
Preparing Stock Solutions
for TRAM 1
The following data is based on the product molecular weight 1009.17
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.99 mL | 4.95 mL | 9.91 mL |
| 5 mM | 0.20 mL | 0.99 mL | 1.98 mL |
| 10 mM | 0.10 mL | 0.50 mL | 0.99 mL |
| 50 mM | 0.02 mL | 0.10 mL | 0.20 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ng Targeted protein relocalization via protein transport coupling. Nature 2024 PMID: 39294374
Product Specific Notices for TRAM 1
For research use only
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