AP 1867
Tocris Bioscience, part of Bio-Techne | Catalog # 6207
Selective binding ligand for FKBP12F36V
Key Product Details
Description
Selective binding ligand for FKBP12F36V
Product Description
AP 1867 is a selective binding ligand for the single point mutant of FKBP12F36V (IC50 = 1.8 nM). Functionalized with a carboxylic acid group at the meta-position to enable onward chemistry. The position of the carboxylic acid group represents an 'exit vector' allowing modification without interfering with the compound's binding ability.Product Specifications
Molecular Weight
693.79
Formula
C38H47NO11
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(1R)-1-[3-(Carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate
CAS Number
195514-23-9
PubChem ID
444590
InChI Key
XCCRAOPQCACRFC-OIFRRMEBSA-N
SMILES
O=C([C@@H]1CCCCN1C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)O[C@@H](C3=CC(OCC(O)=O)=CC=C3)CCC4=CC(OC)=C(OC)C=C4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 69.38 | 100 | |
| Ethanol | 69.38 | 100 |
Preparing Stock Solutions
for AP 1867
The following data is based on the product molecular weight 693.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.44 mL | 7.21 mL | 14.41 mL |
| 5 mM | 0.29 mL | 1.44 mL | 2.88 mL |
| 10 mM | 0.14 mL | 0.72 mL | 1.44 mL |
| 50 mM | 0.03 mL | 0.14 mL | 0.29 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Clackson Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc.Natl.Acad.Sci.U.S.A. 1998 PMID: 9724721
- Koide A synthetic library of cell-permeable molecules. J.Am.Chem.Soc. 2001 PMID: 11456541
Product Specific Notices for AP 1867
For research use only
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