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Endothelin ETB Receptor Antagonists: Small Molecules and Peptides

The endothelinB receptor (ETB receptor) is a member of the endothelin receptor group of G-protein-coupled receptors that also includes ETA. They are located primarily in the vascular endothelial cells where they play a role in vasoconstriction, vasodilation, bronchoconstriction and cell proliferation. The human ETB receptor gene has been localized to chromosome 13 (13q22).

Selective ETB antagonist

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