BQ 788 sodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 1500
Selective ETB antagonist
Key Product Details
Description
Selective ETB antagonist
Product Description
BQ 788 sodium salt is a potent, selective ETB receptor antagonist (IC50 = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells).Product Specifications
Molecular Weight
663.79
Formula
C34H50N5NaO7
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine sodium salt
CAS Number
156161-89-6
PubChem ID
16759603
InChI Key
QCVIFBRTTLMEOV-FUKQNADPSA-M
SMILES
[Na+].CCCC[C@@H](NC(=O)[C@@H](CC1=CN(C(=O)OC)C2=C1C=CC=C2)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C([O-])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.32 | 5 |
Preparing Stock Solutions
for BQ 788 sodium salt
The following data is based on the product molecular weight 663.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 30.13 mL | 150.65 mL | 301.30 mL |
| 0.25 mM | 6.03 mL | 30.13 mL | 60.26 mL |
| 0.5 mM | 3.01 mL | 15.07 mL | 30.13 mL |
| 2.5 mM | 0.60 mL | 3.01 mL | 6.03 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ishikawa Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788. Proc.Natl.Acad.Sci.U.S.A. 1994 PMID: 8197152
- Okada and Nishikibe BQ-788, a selective endothelin ETB receptor antagonist. Cardiovasc.Drug Rev. 2002 PMID: 12070534
- Davenport International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature. Pharmacol.Rev. 2002 PMID: 12037137
Product Specific Notices for BQ 788 sodium salt
For research use only
Loading...
Loading...
Loading...