7 results for "CRF1 Receptor Antagonists Small Molecules and Peptides" in Products
CRF1 Receptor Antagonists: Small Molecules and Peptides
The corticotropin-releasing factor (CRF) 1 receptor is a member of the corticotropin-releasing factor family of G-protein-coupled receptors that also includes CRF2. It is abundantly expressed in the CNS with major expression in the cortex, cerebellum, hippocampus, amygdala, olfactory bulb and pituitary. In the periphery the receptors are expressed at low levels in the skin, ovary, testis and adrenal gland.
Selective non-peptide CRF1 antagonist
| Chemical Name: | 5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride |
| Purity: | ≥98% (HPLC) |
CRF1 antagonist
| Chemical Name: | N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective CRF1 antagonist; anxiolytic
| Chemical Name: | 8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine |
| Purity: | ≥98% (HPLC) |
Potent and selective CRF1 antagonist; binds at an allosteric site
| Chemical Name: | N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine hydrochloride |
| Purity: | ≥98% (HPLC) |
High affinity CRF1 antagonist; orally bioavailable
| Chemical Name: | 3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective, non-peptide CRF1 antagonist
| Chemical Name: | N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride |
| Purity: | ≥98% (HPLC) |
Potent and selective CRF1 antagonist
| Chemical Name: | (7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride |
| Purity: | ≥98% (HPLC) |
