CP 154526

Name: CP 154526
Brand: Tocris Bioscience
SKU: 2779

Tocris Bioscience, part of Bio-Techne | Catalog # 2779

Citations (21)

COA / SDS

Selective, non-peptide CRF1 antagonist

Key Product Details

Description:	Selective, non-peptide CRF₁ antagonist
Chemical Name:	N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	400.99

View Full Technical Details for CP 154526

Technical Data
Citations

Biological Activity for CP 154526

CP 154526 is a selective, non-peptide CRF₁ receptor antagonist (K_i values are 2.7 and > 10000 nM for CRF₁ and CRF₂ receptors respectively). Blocks CRF-induced adenylate cyclase activation (K_i = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for CP 154526

CP 154526 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CP 154526

M. Wt	400.99
Formula	C₂₃H₃₂N₄.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	257639-98-8
PubChem ID	11475094
InChi Key	ZWDLBNCJWNENFF-UHFFFAOYSA-N
Smiles	CC1=CN(C3=C(C)C=C(C)C=C3C)C2=C1C(N(CC)CCCC)=NC(C)=N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 154526

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.05	50
	ethanol	20.05	50

Preparing Stock Solutions for CP 154526

The following data is based on the product molecular weight 400.99.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.99 mL	24.94 mL	49.88 mL
2.5 mM	1.00 mL	4.99 mL	9.98 mL
5 mM	0.50 mL	2.49 mL	4.99 mL
25 mM	0.10 mL	0.50 mL	1.00 mL

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References for CP 154526

References are publications that support the biological activity of the product.

Hodgson Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression. Pharmacol.Biochem.Behav. 2007 PMID: 17291571
Schulz CP-154,526: a potent and selective nonpeptide antagonist of cortico. releasing factor receptors. Proc.Natl.Acad.Sci.USA 1996 PMID: 8816826
Lundkist A non peptidic cortico. releasing factor receptor antagonist attenuates fever and exhibits anxiolytic activity. Eur.J.Pharmacol. 1996 PMID: 8874139