NBI 27914 hydrochloride

Name: NBI 27914 hydrochloride
Brand: Tocris Bioscience
SKU: 1591
Price: 201 USD

Catalog # 1591 | Tocris Bioscience a Bio-Techne Brand

Citations (12)

COA / SDS

Selective non-peptide CRF1 antagonist

Key Product Details

Description:	Selective non-peptide CRF₁ antagonist
Chemical Name:	5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	470.66

View Full Technical Details for NBI 27914 hydrochloride

Biological Activity for NBI 27914 hydrochloride

NBI 27914 hydrochloride is a selective, non-peptide corticotropin-releasing factor₁ (CRF₁) receptor antagonist (K_i = 1.7 nM); has no activity at CRF₂ receptors. Blocks behavioral seizures in vivo.

Compound Libraries for NBI 27914 hydrochloride

NBI 27914 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NBI 27914 hydrochloride

M. Wt	470.66
Formula	C₁₈H₂₀Cl₄N₄.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1215766-76-9
PubChem ID	45073446
InChi Key	CPMGENCTAWBLNW-UHFFFAOYSA-N
Smiles	Cl.CCCN(CC1CC1)C1=C(Cl)C(NC2=C(Cl)C=C(Cl)C=C2Cl)=NC(C)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NBI 27914 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	43.42	100
	DMSO	43.42	100

Preparing Stock Solutions for NBI 27914 hydrochloride

The following data is based on the product molecular weight 470.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.62 mL	21.25 mL
5 mM	0.42 mL	2.12 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for NBI 27914 hydrochloride

References are publications that support the biological activity of the product.

McCarthy Recent advances with the CRF₁ receptor: design of small molecule inhibitors, receptor subtypes and clinical indications. Curr.Pharm.Des. 1999 PMID: 10213797
Baram The CRF₁ receptor mediates the excitatory actions of cortico. releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. Brain Res. 1997 PMID: 9372207
Chen Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor₁ receptor antagonists. J.Med.Chem. 1996 PMID: 8893829

Citations for NBI 27914 hydrochloride (12)

Showing 1 - 10 of 12 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for NBI 27914 hydrochloride include:

Navarro et al. (2015) Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. Stroke. 35:6639
PMID: 25926444
Rajbhandari et al. (2015) Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala NE Systems that Promote PTSD-Like Startle Abnormalities. J Neurosci. 35:14270
PMID: 26490866
Ji et al. (2013) Non-pain-related CRF1 activation in the amygdala facilitates synaptic transmission and pain responses. Mol Pain. 9:2
PMID: 23410057
Jia et al. (2013) Role of nesfatin-1 in a rat model of visceral hypersensitivity. Cereb Cortex. 19:3487
PMID: 23801843
Silberman and Winder (2013) Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala. Neuropharmacology. 70:316
PMID: 23470280
Lowery-Gionta et al. (2012) Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice. J Neurosci. 32:3405
PMID: 22399763
Wang et al. (2011) CRF receptor antagonist astressin-B reverses and prevents alopecia in CRF over-expressing mice. PLoS One. 6:e16377
PMID: 21359208
Liu et al. (2010) Differential actions of urocortins on neurons of the myenteric division of the enteric nervous system in guinea pig distal colon. Br J Pharmacol. 159:222
PMID: 20002096
Delawary et al. (2010) NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala. Mol Brain. 3:37
PMID: 21118530
Nakamura and Sapru (2009) Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors. Am J Physiol Heart Circ Physiol. 296:H2022
PMID: 19395554
Gutknecht et al. (2008) Expression, binding, and signaling properties of CRF2(a) receptors endogenously expressed in human retinoblastoma Y79 cells: passage-dependent regulation of functional receptors. J Neurochem. 104:926
PMID: 17976162
Gallopin et al. (2006) Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex. J Neurosci. 16:1440
PMID: 16339088

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Product Documents for NBI 27914 hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.