Cell Cycle Inhibitors Small Molecules and Peptides

mRNA splicing inhibitor; antitumor

Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9

Cytotoxic agent

Potent and selective Cdc7 inhibitor

Cdk inhibitor

Potent and selective CDK7 inhibitor; induces cell cycle arrest

Stimulates RhoA activation; antiproliferative agent that slows cell cycle progression

Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest

Inhibits c-Myc-Max dimerization

BET bromodomain inhibitor; arrests cell cycle at G1 phase

Potent cdk inhibitor

Potent and selective mTOR inhibitor

5-HT reuptake inhibitor

Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members

Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14

Potent protein synthesis inhibitor

Restores mutant p53 activity

Inhibitor of Bcl-2 family members; antiapoptotic

Potent and selective TAK1 MAPKKK inhibitor

Potent and selective CK2α and CK2α' inhibitor. Also blocks CK2-dependent HIF-1α transcription, causes cell-cycle arrest, induces apoptosis in cancer cells and induces stem cell reprogramming