PRIMA-1MET

Tocris Bioscience, part of Bio-Techne | Catalog # 3710

Restores mutant p53 activity
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Key Product Details

Description

Restores mutant p53 activity

Alternative Names

APR-246

View all Additional p53-related Compounds »

Product Description

PRIMA-1MET is a methylated derivative of PRIMA-1 (Cat. No. 1862). Restores mutant activity p53 activity. Acts synergistically with chemotherapeutic agents to inhibit tumor cell proliferation.

Product Specifications

Molecular Weight

199.25

Formula

C10H17NO3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

CAS Number

5291-32-7

PubChem ID

52918385

InChI Key

BGBNULCRKBVAKL-UHFFFAOYSA-N

SMILES

OCC1(COC)C(C2CCN1CC2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.93 100
DMSO 19.93 100

Preparing Stock Solutions for PRIMA-1MET

The following data is based on the product molecular weight 199.25

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.02 mL 25.09 mL 50.19 mL
5 mM 1.00 mL 5.02 mL 10.04 mL
10 mM 0.50 mL 2.51 mL 5.02 mL
50 mM 0.10 mL 0.50 mL 1.00 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for PRIMA-1MET

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PRIMA-1MET

For research use only

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