4 results for "Additional p53-related Compounds" in Products
Additional p53-related Compounds Products
p53 (aka TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damage, hypoxia and spindle damage). Activation of p53 begins through a number of mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs. MDM2 is a ubiquitin ligase that binds p53 and targets p53 for proteasomal degradation.
Phosphorylation, p14ARF and USP7 prevent MDM2-p53 interactions, leading to an increase in stable p53 ...
Restores mutant p53 activity
| Alternate Names: | APR-246 |
| Chemical Name: | 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one |
| Purity: | ≥98% (HPLC) |
Restores mutant p53 activity; proapoptotic
| Chemical Name: | 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione |
Selective exportin-1 (XPO1/CRM1) inhibitor
| Chemical Name: | (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyridinyl)hydrazide |
| Purity: | ≥98% (HPLC) |
RNA polymerase I inhibitor; also p53 pathway activator
| Chemical Name: | N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide |
| Purity: | ≥98% (HPLC) |
